2BALALFOUR H H.Antiviral drugs[J].N Engl J Med,1999,340(16):1255-1268.
3PESCOVITZ M D,RABKIN J,MERION R M,et al.Valganciclovir results in improved oral absorption of ganciclovir in liver transplant recipients[J].Antimicrob Agents Chemother,2000,44:2811 -2815.
4BOECKH M,BOIVIN G.Quantitation of cytomegalovirus:methodologic aspects and clinical applications[J].Clin Microbiol Rev,1998,11:533-554.
5BOECKH M,LEISENRING W,RIDDELL S R,et al.Late cytomegalovirus disease and mortality in recipients of allogeneic hematopoietic stem cell transplants:importance of viral load and Tcell immunity[J].Blood,2003,101:407 -414.
6LITTER E,STUART A D,CHEE M S.Human cytomegalovirus UL97 open reading frame encodes a protein that phosphorylates the antiviral nucleoside analogue ganciclovir[J].Nature,1992,358:160-162.
7CHOU S,WALDEMER R H,SENTERS A E,et al.Cytomegalovirus UL97 phosphotransferase mutations that.affect susceptibility to ganciclovir[J].J Infect Dis,2002,185:162-169.
8LURAIN N S,SPAFFORD L E,THOMPSON KD.Mutation in the UL97 open reading frame of human cytomegalovirus strains resistant to ganciclovir[J].J Virol,1994,68:4427 -4431.
9BALDANTI F,MICHEL D,SIMONCINI L,et al.Mutations in the UL97 ORF of ganciclovir-resistant clinical cytomegalovirus isolates differentially affect GCV phosphorylation as determined in a recombinant vaccinia virus system[J].Antivir Res,2002,54:59-67.
10CIHLAR T,FULLER M,CHERRINGTON J.Characterization of drug resistance-associated mutations in the human cytomegalovirus DNA poly-merase gene by using recombinant mutant viruses generated from overlapping DNA fragments[J].J Virol,1998,72:5927 -5936.
