摘要
目的研制重酒石酸长春瑞滨脂质微球注射液。方法通过高压均质使乳粒产生高速碰撞和空穴作用,降低乳粒直径,并控制高压均质的压力和次数来提高稳定性。结果重酒石酸长春瑞滨脂质微球注射液的平均粒径为200 nm,包封率为85%,具有良好的稳定性。结论经过制剂稳定性实验及动物安全性实验,表明采用上述制备工艺制备的脂质微球注射液具有一定的稳定性和安全性。
Objective To prepare the vinorelbine bitartrate lipid microsphere for injection. Methods The particle size of the lipid microsphere for injection was significantly reduced by high pressure homogenizer, which mad of fro 1 1 e particles of the lipid microsphere for injection produce high speed impacts and cavitation, The stability pid mierosphere for injection was improved when the homogenizing pressure and cycles were well coned during high pressure homogenization process. Results The particle size of vinorelbine bitartrate lipid microsphere for injection was about 200 nm. The Incorporation radio was 85 %. The vinordbine bitartrate lipid microsphere for injection has got a good stability. Conclusions The stability and rat security tests indicate that the preparation technology of lipid microsphere for injection is reasonable and feasible.
出处
《沈阳药科大学学报》
CAS
CSCD
北大核心
2006年第12期749-753,共5页
Journal of Shenyang Pharmaceutical University
