摘要
目的 探讨辅助生殖技术（ART）治疗后自然流产的发生率及相关因素。方法 2003-01—2005-12对湘雅医院生殖医学中心接受ART治疗后的临床妊娠590例进行分析，了解体外受精-胚胎移植（IVF—ET）、单精子卵浆内显微注射（ICSI）、冻融胚胎移植（FET）的自然流产情况，比较未流产及流产组的既往自然流产史及多胎妊娠率，比较早期流产与晚期流产患者多胎妊娠率及行IVF前宫腔操作次数。结果 ART治疗后自然流产率为12．20％，IVF、ICSI及FET的自然流产率比较差异无显著意义（P〉0．05），而流产组有既往自然流产史者明显高于未流产组，流产组的多胎妊娠率低于未流产组，差异有显著性（P〈0．01）；晚期流产组多胎妊娠率及行IVF前宫腔操作次数明显高于早期流产组，差异有显著性（P〈0、01）。结论 行ART治疗的不孕患者如有多次宫腔操作史，后天性的宫颈管机械损伤不容忽视；当伴多胎妊娠时应考虑孕3～4个月行宫颈环扎术。
Objective To investigate the rate and risk factors for spontaneous abortion among pregnancies produced by assisted reproductive technology（ART） treatment . Methods A retrospective analysis was performed on 590 clinical pregnancies following ART treatment from January 2003 to December 2005. The incidences of spontaneous abortion was estimated among in vitro fertilization-embryo transfer（IVF） and intracytoplasmic sperm injection（ICSI） and frozen embryo transfer（FET） groups. The previous spontaneous abortion and multiple pregnancies were compared between non-abortion and abortion groups. The multiple pregnancies and the frequencies of uterine cavity operation were compared between early abortion and late abortion groups. Results The spontaneous abortion rate produced by ART was 12.20%. There was no significant difference in the spontaneous abortion rate among IVF-ET, ICSI and FET groups（ P 〉 0.05 ）. Compared with non-abortion group, the previous spontaneous abortion increased significantly in abortion group; and multiple pregnancies decreased significantly in abortion group （ P 〈 0. 01 ）. The multiple pregnancies and the frequencies of uterine cavity operation were significantly higher in late abortion group than those in early abortion group （P 〈 0. 01 ）. Conclusion The cervical incompetency caused by infertility treatment should not be ignored, and cervical encerelage for multiple pregnancies following ART treatment should be taken at 3-4months＇ gestation for those patients who underwent repeated uterine cavity operation.
出处
《中国实用妇科与产科杂志》
CAS
CSCD
北大核心
2006年第12期924-926,共3页
Chinese Journal of Practical Gynecology and Obstetrics
关键词
辅助生殖技术
自然流产
多胎妊娠
Assisted reproductive technology
Spontaneous abortion
Multiple pregnancy
