摘要
目的探讨中、小剂量甲氨蝶呤（MTX）肌内注射治疗异位妊娠的药动学及临床疗效、不良反应。方法选择因早期异位妊娠住院患者40例，随机分为2组，均采用MIX保守治疗。A组：50mg·m^-2单次肌注，B组：0．4mg·k^-1·d^-1连续5d肌注。采用荧光偏振免疫分析法测定用药后MIX血清浓度，比较2组药动学参数、疗效和不良反应。结果A组MIX达峰浓度为2．66×10^-6mol·L^-1，维持血药浓度在10^-6mol·L^-1水平6h，10^-8～10^-7mol·L^-1水平42h；B组达峰浓度0．99×10^-1mol·L^-1，维持10^-8～10^-7mol·L^-1水平5d。2组平均cmax比较P〈0．01。A、B组治疗有效率分别为80％和90％。结论MIX治疗异位妊娠疗效好、安全，治疗有效血药浓度在10^-8-10^-7mol·L^-1水平，单次肌注具有疗程短、依从性好的特点。
AIM To explore the phannacokinetics of intramuscular methotrexate（MTX）with low-medium doses in treamaent of ectopic pregnancy and its adverse drug reaction. METHODS Forty cases of early ectopic pregnancy were divided into 2 groups with MTX intramuscular therapy. A single dose of MTX 50mg. m^-2 im, in group A and MTX 0.4 mg.kg^-1. d^-1, im, for 5 d in group B were given respectively. The blood MTX concentration was determined and the results of 2 groups were compared. RESULTS The peak concentration of MTX in group A can reach 2.66 ×10^-6mol. L^-1 and maintain at 10^-6mol.L^-1 for6 h and 10^-8 - 10^-7mol.L^-1 for42 h.The peak concentration of MTX in group B can reach 0.99 ×10^-6mol.L^-1 and maintain at 10^-8 - 10^-7mol.L^-1 for 5 d.The average Cmax between 2 groups showed significantly statistical difference （P 〈 0.01 ）. The effective rates of group A and B were 80% and 90% respectively. CONCLUSION MTX is an effective and safe drug in treatment of ectopic pregnancy and its effective concentration is 10^-8-10^-7mol.L^-1. The advantage of single dose of MTX is its shorter course of treatment and compliance.
出处
《中国临床药学杂志》
CAS
2006年第6期363-365,共3页
Chinese Journal of Clinical Pharmacy
关键词
甲氨蝶呤
药动学
异位妊娠
药物治疗
methotrexate
pharmacokinetics
ectopic pregnancy
pharmacotherapy
