摘要
目的利用每天平均每小时代谢当量(MET)水平来评价体力活动与缺血性心血管疾病(ICVD)的关系。方法1998年秋季对不同地区35～59岁人群进行心血管危险因素抽样调查,并对调查时无冠心病、脑卒中及恶性肿瘤病史的个体进行随访至2005年上半年。结果共有11849名研究对象资料完整,平均随访5．9年,共发生84例ICVD事件。将MET值作为连续变量带入Cox回归模型研究其与心血管发病风险的关系,初步调整人口学因素后总人群、男性、女性、城市及农村人群发病风险均与MET值负相关,其中城市人群有统计学意义HR=0．22(95% CI：0．05～0 95)。进一步调整其他因素后相关性减弱,城市人群显著性消失。结论城市人群平均每小时MET水平与ICVD呈负相关,其对心血管病的保护可能主要通过传统危险因素起作用。
Objective To examine the associations between physical activity measures [metabolic equivalents of energy expenditure （MET） per hour per day] and ischemic cardiovascular diseases （ICVD） in Chinese population. Methods A survey on cardiovascular risk factors was conducted in different areas of China in fall 1998. People aged 35 to 59 but without a history of coronary heart and stroke at baseline were prospectively followed and 11 849 subjects whose information were complete at the end of second follow-up were valid. Cox regression was used to estimate the hazard ratios （HRs） for incident ischemic cardiovascular diseases and the different measures of physical activity. Results During a mean follow-up period of 5.9 years, 84 incident ischemic cardiovascular events were ascertained. We examined the HRs of ischemic cardiovascular events for a 1-unit change in METs value, which were included in the models as continuous variable. There were negative association of METs values found with ischemic cardiovascular events in total, urban, rural, male and female subjects, and statistical significance in the urban （HRs = 0.22,95 % CI ： 0. 05- 0. 95） but the association was weakened after adjustment for demographic factors. When further adjustment for other intermediate factors, the significance in the urban was again attenuated. When the urban males and females, rural males and females were divided into 3 groups according to their respective tertiles and the combination of different population groups, the factors of male/female and urban/ rural were equally distributed in different groups, and no more adjustment in the Cox model. The multivariate- adjusted （age and education attainment） HRs associated with the tertiles, from lowest to highest, were： 1, 1.03 and 0.65 （Ptrend - 0. 170） for the total, 1,0.72 and 0.64 for the urban, 1, 1.49 and0.72 for the rural, 1, 1.05 and 0.59 for men, 1, 0.90 and 0.84 for women. Conclusion The totality of our findings pointed to METs per hour per day seemed to be weakly associated with a reduction in ischemic cardiovascular events incidence among urban middle-aged adults.
出处
《中华流行病学杂志》
CAS
CSCD
北大核心
2006年第11期930-933,共4页
Chinese Journal of Epidemiology
基金
国家"十五"科技攻关课题资助项目(2001BA703816)
关键词
体力活动
代谢当量
缺血性心血管疾病
Physical activity
Metabolic equivalents
Ischemic cardiovascular diseases
