摘要
目的分析自然流产与染色体异常核型之间的关系。方法采用人外周血淋巴细胞培养,常规G显带技术行染色体核型检查,后结合临床资料对其进行分析。结果204对自然流产夫妇中,检出染色体异常16例(平衡易位15例,罗伯逊易位1例),检出率3.82%,较一般人群的染色体异常率为高,差异有显著性(P<0.01);检出染色体多态性39例,检出率9.56%;流产例次染色体异常组(2.94±0.85)及多态性组(2.76±1.45)均较正常染色体组(1.05±1.39)为高,差异皆有显著性(P<0.01)。结论人体夫妇染色体异常是流产的重要原因之一,但染色体多态性方面的因素也不可忽视。对自然流产夫妇进行常规的染色体检查及遗传咨询具有一定的临床意义。
Objective： To analyze the relationship between abnormal cytogenetic and spontaneous abortions. Methods： Chromosomal karyotype studies were performed on routinely cultured peripheral blood lymphocytes. Slides were processed for G -banding with Trypsin - Giemsa by standard techniques. Rusults： There were 16 abnormal karyotypes in 204 couples with spontaneous abortions （ 15 cases were, balanced translocations, 1 case was robertsonian translocation）, the rate of abnormal karyotypes was 3.82%, much higher than that of common population （ P 〈 0.01 ）. There were 39 chromosome heteromorphisms in 204 couples with spontaneous abortions, the rate was 9. 56%. Respectively compared with that on the cases with normal chromosomes, abortion time on the cases with abnormal karyotypes and with chromosome heteromorphisms was significantly high { abortion times ： （2.94 ± 0. 85 ） vs （ 1.05 ±1.39 ）, （2. 76 ±1.45 ） vs （ 1.05 ±1.39 ）, P 〈 0.01, respectively }. Conclusions： The abnormality of chromosome was one of reasons of spontaneous abortions and the effect of chromosome heteromorphism was not be ignored. It is necessary to analyse chromosomal karyotype and genetic counselling in couples with spontaneous abortions.
出处
《中国优生与遗传杂志》
2006年第11期56-57,60,共3页
Chinese Journal of Birth Health & Heredity
关键词
自然流产
染色体
核型分析
Spontaneous abortion
Chromosome
Karyotype analyse
