摘要
目的探讨伴发抑郁症的帕金森病(PD)患者执行功能的特点及抑郁症对PD患者认知功能的影响。方法对2004—2006年在第三军医大学大坪医院门诊和病房就诊的伴发抑郁症的PD患者(PDD组)36例,PD非抑郁症患者(PDND组)44例,进行整体认知功能和执行功能的评定。执行功能评定包括:Stroop字色干扰测验(SCWT)、画钟测验(CDT)和快速语词流畅性测验(RVR)。普通心理学测验:抑郁自评量表(SDS)、汉密尔顿抑郁量表(HAMD)。结果PDD组痴呆发生率为64%(23/36),PDND组痴呆发生率为34%(15/44),经卡方检验差异有统计学意义(P<0.01)。进行相关分析结果显示,SDS和HAMD评分结果具有显著正相关,SDS及HAMD与执行功能测验结果具有相关性,与年龄、MDRSPD评分、Webster评分、Hoehn-Yahr分期、ADL无明显相关(P>0.05)。结论抑郁症对执行功能有显著的影响,伴发抑郁症的PD患者认知功能下降显著,对PD伴发抑郁症的识别和评估是治疗PD的一个重要组成部分,对PD伴发的抑郁症进行治疗可能会改变认知功能障碍。
Objective To study the characteristics of Parkinson disease （PD） accompanied with depression and the influence of depression with cognition of PD patients. Methods Totally 36 patients of PD with depression （PDD） were submitted to group PDD and 44 patients of PD without depression （PDND） as control group PDND All of them were sub- mitted to the followings： executive function assessment include Stroop color -word test （SCWT）, clock drawing test （CDT） and Rapid Verbal Retrieve （RVR）; normal psychological test included SDS and HAMD and the results were analzed. Results The dementia incidence rate in PDD group was 23/36 （64%） which was significantly different from the PDND group＇s dementia incidence rate 15/44 （34%） through chi square test （P 〈 0. 01 ）. The result of Pearson correlation analysis showed that SDS and HAMD scores were positive with executive function scores, excluding age, MDRSPD, Webster, Hoehn-Yahr stage, ADL scores （P〉0.05）. Conclusion Depression can significantly influence the executive function. To recognize and assess depression in PD patients is very important and treatment of depression may ameliorate aspects of cognitive and functional dysfunction in the PD with depression.
出处
《中国实用内科杂志》
CAS
CSCD
北大核心
2006年第11期1724-1726,共3页
Chinese Journal of Practical Internal Medicine
关键词
帕金森病
抑郁
执行功能
认知功能障碍
神经心理学检测
Parkinson＇s disease
Depression
Executive function
Cognitive impairment
Neuropsychological assessment
