摘要
目的评价降阶梯疗法联合支气管肺泡灌洗术治疗急性脑卒中合并肺部感染的疗效。方法2004年1月至2005年9月南京军区福州总医院神经内科将82例急性脑卒中合并肺部感染患者随机分成两组。治疗组40例,采用抗菌药物降阶梯疗法联合支气管肺泡灌洗术治疗;对照组42例,采用常规抗菌药物治疗。分别观察其临床疗效、细菌清除率、肺部感染吸收天数、入住神经科重症监护病房(NICU)天数。结果治疗组的有效率及细菌清除率明显高于对照组(P<0.05),而平均肺部感染吸收时间和平均住NICU时间明显少于对照组(P<0.01)。结论以降阶梯疗法联合支气管肺泡灌洗术为基础的局部与全身抗生素联合治疗策略,是治疗急性脑卒中患者合并肺部感染的有效方法。
Objective To evaluate the effect of the de - escalation therapy of antimicrobial agents combined bronchoalveolar lavage on the treatment of acute stroke complicate pulmonary infection. Methods 80 patients of acute stroke complicated pulmonary infection were randomized into two groups. The method of the de - escalation therapy of antimicrobial agents combined bronchoalveolar lavage was used in therapeutic group （n = 40） while the patients in control group （n = 42） received routine therapy of antimicrobial agents. The effective rate, the bacterial eradication rat, the average time of pneumonia absorption and the average time NICU stay between two groups were compared and analyzed. Results The effective rate and the bacterial eradication rat in therapeutic group were significantly higher than those in control group （P 〈 0. 05 ）. The average time of pneumonia absorption and NICU stay in therapeutic group were shorter than those in control group. Conclusion The de - escalation therapy of antimicrobial agents combined bronchoalveolar lavage is an effective method for the treatment of pulmonary infection in acute stroke.
出处
《中国实用内科杂志》
CAS
CSCD
北大核心
2006年第11期1700-1702,共3页
Chinese Journal of Practical Internal Medicine
