摘要
目的观察益气活血化痰方药对肺纤维化大鼠支气管肺泡灌洗液(BALF)中层粘连蛋白(LN)、Ⅲ型前胶原(PC-Ⅲ)含量及肺组织形态变化的影响。方法用平阳霉素复制大鼠肺纤维化模型,观察对照、模型、中药各组在处理后7、28d的指标变化。结果模型组28d呈明显的肺纤维化形态变化,肺系数7d后明显增加,BALF中LN、PC-Ⅲ含量均明显增高(P<0.01或P<0.05),中药组的各项指标均明显降低(P<0.01或P<0.05)。结论益气活血化痰方药对用平阳霉素诱发大鼠的肺纤维化病变有明显的防治作用。
Objective To observe the effects of complex prescription with the effects of replenishing Qi, activating blood and resolving phlegm on the levels of LN and PC-Ⅲ in BALF and the changes of lung tissue and figure in rat with pulmonary fibrosis. Method The rat model of pulmonary fibrosis was established by injecting pinyamycin, then the changes of the levels of LN and PC-Ⅲ in every group （TCM group, model group and control group） in 7, 28 days respectively were observed. Result There was obvious pulmonary fibrosis morphologic change. Lung quotient increased dearly, and the levels of LN and PC-Ⅲ in BALF increased obviously in 28 days （P〈0.01 or P〈0.05） in the model group. All these quota decreased remarkably （P〈0.01 or P〈0.05） in the TCM group. Conclusion The complex prescription with the effects of replenishing qi, activating blood and resolving phlegm has marked prevention and treatment functions on pulmonary fibrosis pathological process induced by pinyanmycin.
出处
《中国中医药信息杂志》
CAS
CSCD
2006年第11期43-44,共2页
Chinese Journal of Information on Traditional Chinese Medicine
基金
北京中医药大学科研课题
关键词
肺纤维化
层粘连蛋白
Ⅲ型前胶原
益气活血化痰方药
pulmonary fibrosis
LN
PC-Ⅲ
replenishing Qi, activating blood and resolving phlegm
