摘要
目的:评价2种给药方案治疗儿童急性化脓性扁桃体炎的疗效和经济性。方法:采用前瞻性、随机对照的临床研究方法,对头孢他啶连续静脉滴注(A组)与头孢他啶-头孢克肟序贯给药(B组)治疗儿童急性化脓性扁桃体炎的方案进行最小成本分析。结果:2组临床疗效、细菌清除率及不良反应发生率方面的差异均无统计学意义(P>0.05),但B组抗生素费用及治疗总费用均明显低于A组(P<0.001)。结论:儿童急性化脓性扁桃体炎采用头孢他啶-头孢克肟序贯疗法不但安全、有效,而且更加经济、合理。
OBJECTIVE： To evaluate the curative effects and pharmacoeconics of 2 different dosage schemes for pediatric acute suppurative tonsillitis.METHODS： A prospective randomized controlled trial was performed, pediatric acute suppurative tonsillitis patients were treated with 2 dosage schemes,scheme A were ceftazidine by continuous intravenous drip and scheme B were ceftazidine and cefixime by sequential therapy, the cost- minimization analysis was performed on 2 schemes .RESULTS： There were no significant differences between 2 schemes in curative effects, bacteria clearance rates and incidences of ADRs （P 〉 0.05）, whereas the expenditures in antibiotics and the total treatment cost in scheme B were significantly lower than in scheme A（P〈 0.001） .CONCLUSIONS： Sequential use of ceftazidine and cefixime for pediatric acute suppurative tonsillitis is not only safe and effective, but also more economical and reasonable.
出处
《中国药房》
CAS
CSCD
北大核心
2006年第21期1628-1629,共2页
China Pharmacy
