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VM方案新辅助化学治疗在治疗口腔鳞状细胞癌中的意义 被引量:2

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摘要 目的:探讨联合应用长春新碱(vincristine)和甲氨蝶呤(methotrexate)(VM方案)新辅助化学治疗在治疗口腔鳞状细胞癌中的意义。方法:对36例经VM方案新辅助化学治疗的口腔鳞状细胞癌(oralsquamouscellcarcinoma,OSCC)患者治疗前、后的临床和病理资料进行数理分析。结果:经1个疗程VM方案治疗后,临床近期完全缓解6例(17%),部分缓解24例(67%),无效5例(14%),进展1例(3%),总有效率为83%。VM方案新辅助化学治疗后的病理有效率为67%。仅4例出现轻度不良反应。所有患者均能耐受随后的手术治疗,除1例术后感染延迟愈合外,其余伤口愈合良好。结论:VM方案新辅助化学治疗简单易行、高效、低毒,疗程较短,用于治疗OSCC疗效良好,值得临床推广应用。
作者 赵琪 余东升
出处 《新医学》 北大核心 2006年第11期729-730,共2页 Journal of New Medicine
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参考文献6

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