CuI-catalyzed Synthesis of Aryl Thiocyanates from Aryl Iodides

CuI-catalyzed Synthesis of Aryl Thiocyanates from Aryl Iodides

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摘要 An operationally simple and inexpensive catalyst system was developed for the cross coupling of potassium thiocyanate with aryl iodides by using CuI as catalyst, 1, 10-phenanthroline as ligand, and tetraethylammonium iodide as activator. The procedure is applicable for the synthesis of diverse aryl thiocyanates without any exotic, poisonous reagents.

作者 Ye Feng WANG Yuan ZHOU Jia Rui WANG Lei LIU Qing Xiang GUO

机构地区 Department of Chemistry

出处《Chinese Chemical Letters》 SCIE CAS CSCD 2006年第10期1283-1286,共4页 中国化学快报（英文版）

关键词 Cross coupling reaction CUI aryl thiocyanate Aryl Iodide 1 10-phenanthroline. Cross coupling reaction, CuI, aryl thiocyanate,Aryl Iodide, 1, 10-phenanthroline.

分类号 O625.7 [理学—有机化学]

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6[6]Typical experimental procedure for aryl thiocyanate synthesis:A mixture of aryl iodide(2.0mmol),KSCN(2.4 mmol),CuI(0.2 mmol),1,10-phenanthroline(0.4 mmol),and TEAI(0.2mmol)in 2 mL of DMSO was heated at 100℃ under nitrogen atmosphere for 48 h.The resulting suspension was cooled to room temperature and filtered through a 2-3 cm pad of silica gel with 100 ml of EtOAc.The filtrate was concentrated and the residue was purified by chromatography to afford the pure product.

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Chinese Chemical Letters

2006年第10期

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CuI-catalyzed Synthesis of Aryl Thiocyanates from Aryl Iodides

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