摘要
以红细胞为对象，研究了山莨菪碱对外加Ｈ２Ｏ２及氧自由基发生系统（ＦｅＣｌ２，抗坏血酸）的抗氧化作用。结果山莨菪碱可防止Ｈ２Ｏ２诱导的溶血；抑制氧自由基发生系统引起的脂质过氧化物增加，增加红细胞膜的流动性．提示山莨菪碱抗氧化作用是在膜水平上抗氧自由基引发的膜脂质过氧化，保护细胞膜。
The antioxidative action of anisodamine on H2O2 and the generating system of freeradicals(FeCl2 and ascorbic acid)in the erythrocyte was studied.Anitalamine could prevent thehernolysis induced by H2O2 in vitro.The lipid peroxidation caused by the generating system offree radicals was inhibited by anisedamine,and the fiuidity of the erythrocyte membrane was in-creased.The results suggest that the antioxidative action of anisedamine is at the membrane levelcounteracting the membrane lipid peroxidation caused by the free radicls,and thereby,protectsthemembrane.
出处
《广西医科大学学报》
CAS
1996年第2期12-13,共2页
Journal of Guangxi Medical University
基金
区卫生厅青年科学基金
关键词
山莨菪碱
脂质过氧化物
anisodamine
crythrocyte
lipid
peroxide
membrane
fiuidity
microviscosity
