摘要
目的检测妊娠相关蛋白A(PAPP-A)和高敏C反应蛋白(hs-CRP)在不稳定型心绞痛(UAP)患者的血清表达水平。方法将患者分为三组,分别为UAP组(n=30例),稳定型心绞痛(SAP)组(n=28例),正常对照组(n=20例),全部患者均采用酶联免疫吸附法(Elisa)测定血清PAPP-A和超敏免疫透射比浊法测血浆hs-CRP的浓度。结果UAP患者,血清PAPP-A和hs-CRP水平明显高于SAP及对照组水平(P<0.01)。结论PAPP-A及hs-CRP在血清中的水平与冠心病的严重程度有密切相关,提示两者均可作为预测UAP预后的新的敏感的标志物。
Objective to explore the expression of Pregnancy-associated Plasma Protein-A （PAPP-A） and high-sensitivity Creactive protein（hs-CRP） in the sera of patients with unstable angina pectoris （UAP）. Methods 78 patients with UAP were randomly divided into three groups, including unstable angina pectoris （UAP） group （ n = 30）, stable angina pectoris （SAP） group （ n = 28 ） and normal control group （ n = 20）. The serumal levels of PAPP-A and hs-CRP in 78 cases were detected respectively by enzyme-linked immunosorbent assay（ELISA） and supersensitivity immunity turbidimetry（SSIT）. Results The serumal levels of PAPP-A and hs-CRP in the patients with UAP were significantly higher than those in SAP and .Normal control group （P〈0.01）. Conclusions The serumal levels of PAPP-A and hs-CRP are positive correlation with degree of coronary heart disease. They are sensitive markers for predicting the prognostic of UAP.
出处
《实用全科医学》
2006年第6期641-642,共2页
Applied Journal Of General Practice
基金
深圳市宝安区科技立项目(项目编号:2005182)
