摘要
目的探讨代谢综合征(MS)的肾脏损害。方法MS组25例,非MS组28例。测量体重指数(BMI)和血压,检测血甘油三酯(TG)、高密度脂蛋白(HDL)、空腹血糖(FBG)、血尿酸(UA)、血肌酐、血及尿β2微球蛋白(β2-MG)、尿白蛋白排泄率(UAER)、尿pH值和尿密度。探测肾脏大小、肾叶间动脉收缩期峰值流速(Vmax)、舒张末期流速(Vmin)和阻力指数(RI)。结果MS组与非MS组比较,前者血和尿β2-MG、UAER、尿pH值均升高(P均<0.05),尿密度下降(P<0.05)。肾叶间动脉Vmax及Vmin下降,RI上升(P均<0.01)。两组血肌酐和肾脏大小差异均无统计学意义(P均>0.05)。结论MS肾脏损害表现为UAER升高,肾小管功能改变,肾血流表现为低速高阻,肾灌注下降。MS症候群可引起或加重肾脏损害。
Objective To explore renal injury due to metabolic syndrome. Methods Twenty-five cases of metabolic syndrome and 28 cases of non-metabolic syndrome were enrolled. Body mass index （BMI）, blood pressure, triglyceride （TG）, high dense lipoprotein（HDL）, fasting blood glucose（FBG）, uric acid（ UA ）, serum creatinine, 13 2 microglobulin, urinary albumin excretion rate（UAER）, urinary pH and specific gravity were detected. Size of renal, systolic peak velocity and diastolic velocity of interlobar artery were detected. Results 132 microglobulin in serum and urine, UAER and urinary pH in metabolic syndrome were higher than those in non-metabolic syndrome. Specific gravity of urine in metabolic syndrome was lower than that in non-metabolic syndrome. The systolic peak velocity and diastolic velocity of interlobar artery in metabolic syndrome were lower, and resistive index was higher than that in non-metabolic syndrome. Conclusions The renal injury due to metabolic syndrome manifests by increased UAER and changes of tubular function. The renal artery is at a state of low systolic and diastolic flow velocities and high renal vascular resistance. The renal injury due to metabolic syndrome is related with obesity, hypertension, hyperlipidemia, hyperglycemia, and hyperuricemia.
出处
《中国医师进修杂志》
2006年第8期19-21,共3页
Chinese Journal of Postgraduates of Medicine
关键词
代谢综合征
肾脏损害
Metabolic syndrome
Renal injury
