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MSTN基因在动物科学和医学中的研究进展 被引量:9

Progresses on Studies of Myostatin Gene Applied in Animal Science and Medicine Areas
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摘要 作为转化生长因子β(TGF-β)超家族成员之一的肌肉生长抑制素myostatin(MSTN),又称GDF-8(Growthdifferentiation factor 8),与同属于同一个家族的生长激素(GH)、类胰岛素生长因子(IGF)等因子对动物生长发育的调节作用有所不同,MSTN基因是一种对骨骼肌生长具有负调空作用的重要的细胞因子,它的突变或缺失会导致肌肉细胞的增生和肌纤维的肥大[1]。本文详细阐述了抑肌素的基因结构、表达蛋白的功能、基因定位和基因表达谱以及在动物科学和医学中的应用和研究最新进展。 As a member of the transforming growth factor - βfamily, Myostatin (MSTN), unlike with the other members which contain GH, IGF, et al, performs as a negative regulator of muscle growth . When it mutates or losts, it will lead to myocyte hyperplasia and increase the number of muscle fibers. This paper expatiates MSTN' s gene structure, fuctions of protein, location of gene & gene expression , latest progress in research and appied in animal science and medicine.
出处 《草食家畜》 2006年第2期24-26,31,共4页 Grass-Feeding Livestock
关键词 肌肉生长抑肌素 肌肉 双肌 表达 抑制作用 myostatin musle duble - musle expression inhibition
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参考文献20

  • 1McPherron AC,Lee SJ.Double muscling in cattle due to mutations in the myostatin gene. Proc Natl Acad Sci USA,1997;94:12457~12461.
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二级参考文献1

  • 1I. Hoeschele. Genetic evaluation with data presenting evidence of mixed major gene and polygenic inheritance[J] 1988,Theoretical and Applied Genetics(1):81~92

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