摘要
目的研究血清白细胞介素-6(interleukin-6,IL-6)与妊娠糖尿病(gestational diabetes mellitus,GDM)胰岛素抵抗(insulin resistance,IR)的关系。方法GDM组(病例组)选取GDM58例,2型糖尿病(type 2 diabetes mellitus,T2DM)组(阳性对照组),选取T2DM34例,正常对照组选取同期正常孕妇84例。测定他们的空腹血糖、血脂、糖化血红蛋白(HbAIC)、血清胰岛素及IL-6；多元回归法分析IL-6与IR、血脂的相关性。结果与正常孕妇相比,GDM组及T2DM组的IL-6、IR均显著升高(P＜0．05,P＜0．01)但两组间无显著性差异。多元回归分析显示,在GDM组及T2DM组中,IL-6与IR、甘油三酯(TG)、HbAlC成正相关。结论GDM与T2DM有共同的发病基础；IR及炎症因子参与了GDM的发病。
Objective To study the relationship between serum IL-6 and insulin resistance in gestational diabetes mellitus（GDM）. Methods 58 gestational diabetes mellitus, 34 Type 2 diabetes mellitus and 84 Controls were involved in the study. Insulin Resistance （IR） Value was assessed by homeostasis mode assessment （HOMA）. Serum IL-6 and blood lipoid were measured in fasting state. The correlations between IL-6, 1NS-R and blood lipoid were determined by multiple linear regression analysis. Results Serum IL-6 and insulin resistance were significantly higher in GDM than in the controls. In GDM group, the serum IL-6 levels correlated positively with IR, triglycerides, HbA1C. Conclusion GDM was associated with higher levels of serum IL-6 and higher IR.
出处
《医学新知》
CAS
2006年第4期215-216,共2页
New Medicine
关键词
白细胞介素-6
妊娠糖尿病
胰岛素抵抗
Interleukin-6
gestational diabetes mellitus
insulin resistance
