摘要
目的研究恶性肿瘤转移时患者高凝状态的改变。方法采用SYSMEXCA-7000型血液凝固仪测定D-二聚体D(D)、抗凝血酶活性A(TA:)、凝血因子Ⅷ活性F(ⅧA:)、vW因子v(onWellibrandFactor,vWF)、纤维蛋白原(FIB)。结果转移癌患者DD、vWF水平显著高于未转移组和对照组(P<0.01),ATA:显著低于未转移组和对照组(P<0.01),FⅧA:、FIB水平与未转移组和对照组比较,差别无统计学意义(P>0.05)。此现象亦发生于肿瘤患者血管生成组,且更为显著。结论肿瘤转移患者处于高凝状态,与肿瘤组织血管生成密切相关;DD、vWF、ATA:可发生显著改变,具有较高的敏感性和特异性,FⅧA:、FIB敏感性、特异性较低。
Objective To study the hypercoagulable state in the patients with malignant metastasis tumor. Methods With the SYSMEX CA-7000 blood coagulation instrument, the blood coagulable state profiles including the D-Dimer （DD）, anti-thrombin activity （AT：A）, factor Ⅷ activity （FⅧ：A）, yon Willebrand factor （vWF） and fibrinogen （FIB） were detected in metastasis group, nonmetastasis group and control group. Results Compared with the non-metastasis and control group, the levels of the DD and vWF in metastasis group were increased obviously （P〈0.01）, and AT：A was significant lower （P〈0.01）, but the levels of the FW and FIB had no significant change between these three groups （P〉0.05）. The changes mentioned above were more significant in tumor patient with blood vessel developing. Conclusion The patients with metastasis tumor had the hypercoagulable state, and there was a strong relationship between the hypercoagulable state and the blood vessel developing; DD, vWF, AT had strong sensitivity and speciality, but FⅧ：A and FIB weak.
出处
《中国慢性病预防与控制》
CAS
2006年第4期241-242,共2页
Chinese Journal of Prevention and Control of Chronic Diseases
