摘要
目的探讨放射性肺炎发生的影响因素，以指导肺癌治疗计划的制定，避免和减少正常肺组织的放射损伤。方法总结208例需行放疗的Ⅱ～Ⅲb期肺癌患者的治疗情况，分析年龄、性别、病理、临床分期、肿瘤位置、化疗、手术、肺部疾病、放疗剂量及放疗机类型对放射性肺炎发生率的影响。应用SPSS10．0进行x^2检验的单因素分析、Logistic多元回归分析筛选影响因素。结果放疗剂量与放射性肺炎发生率相关；女性高于男性；周围型高于中心型；单纯放疗者高于术后放疗者；合并有慢性支气管炎、肺气肿的患者高于肺部无基础疾病者；采用15MV—X线加速器放疗者低于^60Coγ射线治疗者；而患者年龄、临床分期、病理类型、是否合并化疗与放射性肺炎的发生无明显关系。结论在制定肺癌放射治疗计划时，充分考虑患者的合并症、照射剂量和放疗机类型等因素，可减少放射性肺炎的发生。
Objective To identify the risk factors of radiation pneumonia （RP） induced by radiotherapy in lung cancer. Methods A retrospective study was conducted on 208 patients with radiation pneumonia using multivariate analysis with SPSS 10.0. The following factors were evaluated： age, gender, pathological type, clinical stage, tumor site, chemotherapy, surgery and accompanied lung diseases, irradiation dose, type of irradiation. Univariate analysis was performed using Chi- Square test and multivariate analysis was performed using Logistic regression model. Results The multivariate analysis showed that RP was associated with gender, tumor site, accompanied lung disease, irradiation dose, type of irradiation; not associated with age, pathology, clinical stage, chemotherapy. Conclusion To minimize the occurrence of radiation pneumonia, the risk factors should be considerate when the radiotherapy of lung cancer is being planed.
出处
《实用肿瘤杂志》
CAS
2006年第4期302-305,共4页
Journal of Practical Oncology
关键词
肺肿瘤/放射疗法
肺肿瘤/并发症
辐射性肺炎/病因学
因素分析
统计学
lung neoplasms/radiotherapy
lung neoplasms/complication, radition pneumonitis/etiology
factor analysis, statistical
