摘要
目的观察PPAR-γ的激动剂吡咯列酮对肝癌细胞的生长抑制作用。方法采用MTT法研究了不同浓度盐酸吡咯列酮与肝癌细胞株SMMC7721的生长抑制作用,并观察了不同时间对SMMC7721的生长抑制作用。结果吡咯列酮对肝癌细胞有明显抑制作用,随着浓度的升高吡咯列酮对肝癌细胞的生长抑制作用逐渐增强;在高浓度组(20μM以上),在一定的时间范围内(24～120h)随着作用时间延长,抑制作用逐渐增强。结论PPAR-γ的激动剂吡咯列酮可抑制肝癌细胞的生长,并且呈剂量和时间依赖关系。
Objective TO study the effect of Pioglitazone, a Ligand of Peroxisome proliferator-aetivated receptor-gamma, for Antiproliferation in hepatocellular carcinoma （HCC） cell lines（SMCC7721）. Methods HCC line SMMC7721 was treated with different concentration of Pioglitazone. Antiproliferation effects was measured by MTT methed at 24, 48 and 72h. Results The growth inhibition effects of Pioglitazone were enhanced along with increase of concentration and time （in groups of eoneentration≥20μM）. Conclusion Pioglitazone can inhibit the growth of HCC cell line in vitro, and the inhibit was dose-depending and time-depending.
出处
《江西医药》
CAS
2006年第7期449-451,共3页
Jiangxi Medical Journal
