摘要
目的探讨丙泊酚在危重烧伤动物模型休克期的药代动力学特点。方法20只新西兰大白兔,随机均分为烧伤休克期组(S组)和对照组(C组)。将S组兔制成30%体表总面积(TB-SA)的Ⅲ度烫伤,并进行复苏,烫伤6h后单次静脉注射5·1mg/kg丙泊酚,利用高效液相色谱仪(HPLC)检测注药后1、3、10、20、30、45、60、90min兔血浆丙泊酚浓度。用3P97药代动力学计算程序处理血药浓度数据,拟合房室模型,计算药代动力学参数。结果各组分别有8只兔完成实验数据采集,S组血浆丙泊酚浓度在1min时明显低于C组(P<0·01),而从30min开始直至90min,明显高于C组(P<0·01)。S组符合二室开放模型,C组符合三室开放模型;S组中央室分布容积(VC)、曲线下面积(AUC)增大(P<0·01),消除半衰期(t1/2β)延长(P<0·05),清除率(CL)降低(P<0·05)。结论丙泊酚在危重烧伤兔模型中休克期药代动力学参数变化明显,较正常兔分布半衰期(t1/2α)、t1/2β延长,VC增大,CL降低。
Objective To study the characteristics of propofol pharmacokinetics used during shock phase in severe burns rabbit model. Methods Twenty New Zealand rabbits were randomly assigned to shock phase group （group S） and control group of shock phase （group C）. The rabbits of group S were thermal injured with hot water （98℃） full thickness to thirty percent of total body surface area, and resuscitated instantly, six hours later were injected with propofol 5.1 mg/kg, the plasma propofol concentrations were determined at 1, 3,10,20,30,45, 60,90 min after injected by high performance liquid chromatography（HPLC）. Data of propofol concentration were analyzed and the compartment model were fitted with 3P97 program, then the best pharmacokinetic parameters and compartment model were chose according to AIC value and F value. Results Eight rabbits finished experiment in two groups respectively, group S fitted on two-compartment open model,group C fitted on three-compartment open model; Comparing with group C,Vc, AUC of group S increased significantly（P〈0.01） ,t（1/2β） prolonged （P〈0.05） ,CL decreased（P〈0.05）. Conclusion Propofol pharmacokinetic parameters evidently changed in severe burns rabbit model during shock phase, distribution half time and elimination half time prolonged, distribution volume increased, clearance decreased either contrast to normal rabbits.
出处
《临床麻醉学杂志》
CAS
CSCD
2006年第7期525-527,共3页
Journal of Clinical Anesthesiology
关键词
丙泊酚
烧伤
麻醉
药代动力学
Propofol
Burns
Anesthesia
Pharmacokinetics
