摘要
目的筛选复方甲亢片喷雾制粒的最佳工艺条件。方法应用正交试验法,以颗粒均匀度、大小和颗粒中黄芪甲苷含量为考察指标,并结合颗粒吸湿速率,对影响复方甲亢片喷雾制粒过程的主要因素进行考察。结果最佳工艺参数为主风机频率35.0±5Hz,雾化压力0.1mPa,喷雾速度1.2Hz,稠膏密度1.20g/mL;结论该方法制出的颗粒均匀结实,性质稳定,利于制剂压片成型。
Objective To optimize the spray pelletization technology for Compound Jiakang Tablets. Methods The experiment was performed by orthogonal design, and the inspection criteria key were granule uniformity, granule size and the content of astragaloside IV, combined with the granule hygroscopic velocity. Results The optimal spray pelletization parameters were as follows： the frequency of main fan was （35.0 ± 5） Hz, atomizational pressure was 0. 1 mPa, the rate of spray was 1.2 Hz, the density of extract was 1.20 g/mL. Conclusion The granules made by this technology are uniform, burly, stable, and are beneficial for pressing into tablet.
出处
《中药新药与临床药理》
CAS
CSCD
2006年第4期291-293,共3页
Traditional Chinese Drug Research and Clinical Pharmacology
关键词
复方甲亢片
喷雾制粒
正交试验
Compound Jiakang Tablets
Spray pelletization technology
Orthogonal design
