摘要
目的:探讨胃癌组织中白介素12(IL12)与白介素18(IL18)的表达,及其与胃癌临床病理特征、血管生成及预后的关系。方法:选取50例胃癌标本,通过免疫组化检测IL12与IL18在胃癌组织中的表达,显微图像分析系统测定微血管密度。结果:IL12与IL18在胃癌中的阳性表达率分别为44%(22/50)和26%(13/50),IL12与病理分化(P=0.029)、浸润深度(P=0.002)、淋巴结转移(P=0.002)、远处转移(P=0.003)和TNM分期(P=0.005)相关,IL18与远处转移密切相关(P=0.001);多因素生存分析显示IL12、MVD和T分期是胃癌的独立预后因素。结论:IL12和IL18阳性表达与肿瘤进展和转移有关,IL12是提示胃癌患者预后不良的独立因素。
Objective：To examine the expressions of interleukin-12 （IL-12） and interleukin-18 （IL-18） in gastric cancer and their association with clinicopathologic features, angiogenesis, and prognosis of gastric cancer. Methods：The expressions of IL-12 and IL-18 in 50 samples of gastric cancer tissues were analyzed by immunohistochemistry. The microvessel density （MVD） was determined with microscopic imaging analysis system. Results：The positive rates of IL-12 and IL-18 expression were 44% （22/ 50） and 26% （13/50）, respectively. IL-12 expression was significantly correlated with pathologic differentiation （P=0. 029）, depth of invasion （P=0. 002）, lymph node metastasis （P=0. 002）, distant metastasis （P=0. 003）, and TNM stages （P= 0. 005）. IL-18 expression was closely related to distant metastasis （P=0. 001）. The multivariate survival analysis revealed that IL-12, MVD and T stage were independent prognostic factors of gastric cancer. Conclusion： The positive expressions of IL-12 and IL-18 correlated with development and metastasis of gastric cancer. IL-12 is an independent factor of poor prognosis of gastric cancer.
出处
《肿瘤》
CAS
CSCD
北大核心
2006年第7期672-676,共5页
Tumor
