摘要
目的探讨结肠癌根治术后肿瘤转移复发的特点和影响预后的因素。方法回顾性分析310例结肠癌患者根治术后转移复发的特点,并对预后进行单因素及多因素分析。结果本组患者结肠癌行根治术后转移复发率为23．2%(72例)。其中3年内转移复发者占76．4%(55例)。肝转移28例(38．9%),多脏器转移16例(22．2%)。x^2检验显示,肿瘤大体类型、分化程度、有无淋巴结转移、Stage分期与转移复发相关。本组5年生存率64．6%。单因素分析显示,肿瘤大体类型、组织学类型、分化程度、淋巴结转移、脉管瘤栓、Stage分期、有无化疗和门脉化疗与预后相关；多因素分析显示,肿瘤大体类型、淋巴结转移、术后有无化疗和门脉化疗为影响预后最重要的因素。结论结肠癌患者根治术后转移复发多在3年内,肝脏是最常见的转移部位。肿瘤大体类型、淋巴结转移、有无化疗和门脉化疗是结肠癌术后影响预后的重要因素。
Objective To investigate the characteristics of metastasis and recurrence following curative resection for colonic carcinoma, and analyze the prognosis. Methods The clinicopathological and follow-up data of 310 patients with colon carcinoma undergoing curative resection were analyzed retrospectively. Results The recurrence rate after curative resection was 23.2% （72/310） . The 5-year survival rate was 64.6%. Hepatic metastasis accounted for 38.9% of the cases. Gross classification, histological type, differentiation, lymph node metastasis were correlated with metastasis/recurrence. Univariate analysis revealed that gross classification, histological type, differentiation, lymph node metastasis, blood vessel invasion, TNM Stage, postoperative chemotherapy, portal chemotherapy were prognostic factors. Cox regression analysis revealed that only gross classification, lymph node metastasis, postoperative chemotherapy, portal chemotherapy were independent prognostic factors. Conclusions Liver is the most common metastatic site after curative resection for colonic carcinoma. Gross classification, lymph node metastasis, postoperative chemotherapy, and portal chemotherapy are independent prognostic factors.
出处
《中华胃肠外科杂志》
CAS
2006年第4期291-293,共3页
Chinese Journal of Gastrointestinal Surgery
关键词
结肠肿瘤
外科手术
肿瘤转移
肿瘤复发
预后
Colonic neoplasms
Surgical procedures, operative
Neoplasms metastasis
Neoplasms recurrence
Prognosis
