摘要
目的本研究旨在分析β3肾上腺素受体Trp64Arg遗传多态性在中国汉族高血压人群中的分布特征及其与肥胖发生的相关性。方法采用聚合酶链式反应-限制性片断长度多态性方法对受试者进行基因型分析。结果对437名中国汉族受试者β3肾上腺素受体Trp64Arg等位基因进行基因型分析,发现Arg/Arg突变基因型组发生肥胖的频率显著高于Trp/Trp基因型组(P=0.007);而Arg/Arg突变基因型组发生高血压的频率与Trp/Arg和Trp/Trp基因型组均无明显差异。结论结果提示β3肾上腺素受体Arg/Arg基因变异可能是中国汉族人群肥胖症发病的一种危险因素。
[Objective] To investigate the association between β3-adrenoceptor Trp64Arg polymorphism and susceptibility of obesity and hypertension in Chinese Han population. [Methods] . Genotype analysis was done using polymerase chain reaction-restrict fragment length polymorphism （PCR-RFLP）. [Results] In 437 chinese volunteers of Han nationality, the frequency of obesity in the group of Arg/Arg genotype was significantly higher than that in the Trp/Trp and Trp/Arg groups. Further study showed the frequency of hypertension is not different among these three groups. [Conclusion] These data suggest that Arg/Arg gene variation of β3-adrenoceptor may be a dangerous factor to obesity pathogenesis in Chinese Han nationality.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2006年第12期1811-1814,共4页
China Journal of Modern Medicine
基金
国家自然科学基金资助课题
No30070880
国家教育部优秀青年教师资助计划
教人司[2002J]350号
