摘要
目的探讨绝经后妇女低剂量与长期的性激素替代疗法（HRT）对血脂水平的影响.方法研究对象为北京协和医院女职工141人,年龄50～87岁、平均68岁,其中绝经后低剂量HRT 5～31年63人为HRT组.以年龄匹配78人为对照组.空腹12～14 h取静脉血,分离血清,检测血脂、脂蛋白和载脂蛋白等九项指标.结果HRT组与对照组比较：甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、载脂蛋白AⅠ（ApoAⅠ）、脂蛋白（a）[Lp（a）]两组之间差异无统计学意义;总胆固醇（TC）、TC/HDL-C、载脂蛋白E（ApoE）、载脂蛋白CⅢ（ApoCⅢ）和载脂蛋白B（ApoB）差异有统计学意义. 结论绝经后妇女经低剂量与长期的HRT可使TC、ApoB、ApoCⅢ、ApoE、TC/HDL-C水平明显下降.血脂水平的下降对心血管系统有保护作用,并可降低心血管事件发生和发展的危险性.
Objective： To study the effects of low-dose blood lipids in postmenopausal women. and long-term hormone replacement therapy （HRT） on Methods： A total of 141 postmenopausal female medical staff （aged 50 to 87 years, average 68 years） from Peking Union Medical College Hospital were recruited. Among them, 63 received low-dose HRT for 5～31 years were taken as HRT group, and other 78 age-matched postmenopausal women as the control group. Vein blood was taken from the women fasting for 12～14 h and the serum isolated for the determination of serum concentrations of lipid, lipoprotein and apolipoprotein. Data were analyzed with SPSS statistical software and the statistical significance was considered to be P〈0.05. Results： In comparison with the controls, the levels of TG, HDL-C, LDL-C, ApoA, Lp（a） in the women of HRT group had no significant difference, but those of TC, TC/HDL-C, ApoE, ApoCⅢ and ApoB significantly decreased. Conclusions： The serum levels of TC, LDL-C, ApoB, ApoCⅢ, ApoE decrease obviously in the postmenopausal women receiving low-dose and long-term HRT. The decrease of blood lipid levels may protect cardiovascular system and reduce the risk of cardiovascular events.
出处
《生殖医学杂志》
CAS
2006年第3期157-160,共4页
Journal of Reproductive Medicine
基金
科技部1999年度攀登-特别支持费资助(国科基字[1999]045)
关键词
血脂
激素替代疗法
绝经后妇女
Lipid
Hormone replacement therapy
Postmenopausal women
