1Tao X, Cush JJ,Garret M,et al. A phase I study of ethyl acetate extract of the Chinese antirheumatic herb Tripterygium wilfordii hook F in rheumatoid arthritis[J]. J Rheumatol, 2001 ;28(10):2160
2Cibere J,Deng Z,Lin Y,et al. Randomized double-blind placebo-controlled study of Tripterygium wilfordii, a Chinese herbal therapy, in rheumatoid arthritis[J]. Arthritis Rheum, 2000;43(1):1345
3Chen BJ. Tfiptolide, a novel immunosuppressive and anti-inflammatory agent purified from a Chinese herb Tripterygium wilfordii Hook F[J]. Leuk Lymphoma, 2001 ;42(3):253
4Yang Y,Liu Z,Tolosa E,et al. Triptolide induces apoptotic death of T lymphocyte[J]. Immunopharmacology, 1998 ;40(2):139
5Qiu D,Zhao G,Aoki Y,et al. Immunosuppressant PG490 (triptolide) inhibits T-cell interleukin-2 expression at the level of purine-box/nuclear factor of activated T-cells and NF-kappaB transcriptional activation[J]. J Biol Chem.1999;274(19): 13443
6Hu KB,Liu ZH,Liu D,et al. Inhibition of vascular endothelial growth factor expression and production by triptolide [J].Planta Med, 2002; 68(4):368
7Liu H,Liu ZH,Chen ZH,et al. Triptohde: a potent inhibitor of NF-kappa B in T-lymphocytes[J]. Acta Pharmacol Sin,2000; 21 (9):782
8Tao X,Schulze-Koops H,Ma L,et al. Effects of Tripterygium wilfordii hook F extracts on induction of cyclooxygenase 2 activity and prostaglandin E2 productlon[J]. Arthritis Rheum, 1998;41(1):130
9Lin N,Sato T, Ito A. Triptolide, a novel diterpenoid triepoxide from Tripterygium wilfordii Hook. f., suppresses the production and gene expression of pro-matrix metalloproteinases 1 and 3 and augments those of tissue inhibitors of metalloproteinases 1 and 2 in human synovial fibroblasts[J]. Arthritis Rheum, 2001 ;44(9):2193
10Gaudin P, Razakaboay M,Surla A,et al. A study of metalloproteinases in fifty joint fluid specimens[J]. Rev Rhum Engl Ed, 1997 ;64(6): 375
