摘要
目的 了解深圳市无偿献血者梅毒感染现状，为安全输血招募低危无偿献血者提供科学的理论依据。方法 用甲苯胺红不加热血清试验（TRUST）及酶联免疫吸附试验（ELISA）对献血者进行梅毒抗体筛检，阳性者用梅毒螺旋体明胶凝集试验（TPPA）确认。同时比较不同时间、年龄、性别、文化程度及职业分布上的感染率，找出降低输血风险的有效方法。结果 深圳市2000-2004年220218名无偿献血者的梅毒感染率为5．60‰，呈逐年上升趋势，以31～50岁年龄段感染率较高（P〈0．005），商务和外来劳务工的梅毒感染率远高于其他职业人群。结论 梅毒在深圳市呈一定的流行势态，应建立一支固定的志愿无偿献血者队伍，提高试剂的灵敏度和特异性，切实做好无偿献血者梅毒血清筛查工作，进一步确保输血安全。
Objective To investigate the Treponema pallidum infection rate in blood donors in Shenzhen City and to provide scientific basis for blood transfusion safety and the recruitment of low risk blood donors. Methods Toluidine red unheated serum test （TRUST） and enzyme- linked immunosorbent assay （ELISA） were used to screen the antibody against Treponema pallidum among the blood donors, the positive samples were further confimed by T. pallidum particle agglutination （TPPA） test again. The prevalence of different time periods, subjects＇ age, sex, culture and occupation were compared. Results The infection prevalence of syphilis was .5.60%o in all 220,218 donors and the prevalence was increased rapidly from 2000 through 2004. The infection rate of donors between 31 and 50 years old was the highest（P〈0. 005）, and the imported merchants and labors had higher prevalence. Conclusion Syphilis has not yet been controlled effectively though it has increased prevalence in Shenzhen City. It is necessary to establish a regular non- risk blood donor team. Improvement of sensitivity and specificity of the reagents and the programs on screening the antibody against T. pallidum among the blood donors are urgent to further blood transfusion safety.
出处
《实用预防医学》
CAS
2006年第3期574-576,共3页
Practical Preventive Medicine
关键词
献血者
梅毒
苍白密螺旋体
血液筛查
Blood donor
Syphilis
Treponema pallidum
Blood screening
