摘要
为研究食管癌相关基因2(ECRG2)STR多态性与新疆汉族食管癌易感性的关系,在新疆地区进行了一个食管癌研究(食管癌84例,人群对照53例),采用PCR-SSCP技术检测研究对象的ECRG2 STR基因型。结果显示:ECRG2STR呈多态性,可分为3种类型:TCA3/TCA3,TCA4/TCA4,TCA3/TCA4,在有转移的食管癌中分布为67.9%、7.1%、25.0%,在无转移的食管癌中分布为14.3%、44.6%、41.1%,两者相比,有显著差异(χ2=26.18,df=2,P<0.01)。在病例对照研究中,在食管癌中所占比例分别是32.1%、32.1%、35.8%,对照组分别是15.1%、49.1%、35.8%,两组总构成比有显著差异(χ2=6.10,P=0.047)。由此可知ECRG2基因TCA3/TCA3基因型与TCA4/TCA4基因型比较,增加了患食管癌和发生转移的风险。
To investigate the relation between polymorphism of Esophageal Cancer Related Gene （ECRG2）STR and susceptibility in Xinjiang＇ s esophageal squamous cell cancer（ESCC）. Methods： A case-control study was conducted with 84 ease of esophageal cancer and 53 population based controls in high incidence area of ESCC of xinjiang. ECRG2 genotypes were detected by PCR-SSCP method. Result： The frequencies of ECRG2 STR genotypes, TCA3/TCA3, TCA4/ TCA4,TCA3/TCA4 were 67.9% ,7.1% ,25.0% in metastasis esophageal cancer, and 14.3% ,44.6% ,41.1% in cases who have no metastasis respectively, statistical difference between them was found（χ^2 = 26.18, P 〈 0.01 ）.The frequencies of ECRG2 STR genotypes TCA3/TCA3, TCA4/TCA4, TCA3/TCA4 were32. 1%, 32. 1%, 35.8% in esophageal cancer, and 15.1% ,49.1% ,35.8%in control respectively, statistical difference between them was found（χ^2 = 6.100, P = 0.047） Conclusion： Subjects who carried the TCA3/TCA3 genotype were an increased risk of ESCC and metastasis compared to those carting the TCA4/TCA4 genotype.
出处
《石河子大学学报（自然科学版）》
CAS
2006年第2期142-145,共4页
Journal of Shihezi University(Natural Science)
基金
教育部科学技术研究重点项目(206167)
