摘要
目的分析急性心肌梗死患者入院时血浆高敏C反应蛋白（hs-CRP）水平和直接经皮冠状动脉介入治疗（PCI）术后心肌灌注的关系.方法选择2001年10月-2004年12月在我院住院治疗的首发急性心肌梗死患者197例,其中男154例,女43例,平均年龄（60.94±11.62）岁.TIMI心肌灌注分级（TIMI myocardial perfusion grade,TMPG）0～1级患者为Ⅰ组（n=39,19.8%）,TMPG2～3级患者为Ⅱ组（n=158,80.2%）.所有入选患者第一次空腹静脉血检测甘油三酯、总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、hs-CRP;并在发病后2、6、10、12、16、24、48、72 h静脉抽血测定肌酸激酶同工酶;发病48 h内超声心动图测定左室射血分数值.结果两组患者之间年龄、性别、病史差异无统计学意义.Ⅰ组与Ⅱ组比较,入院时血浆hs-CRP水平差异有统计学意义[（8.29±4.75）mg/L比（6.38±4.73）mg/L,P=0.026].肌酸激酶峰值[（3017.85±1901.19）U/L比（2701.41±1992.97）U/L]、肌酸激酶同工酶峰值[（442.37±333.29）U/L比（355.91±287.99）U/L]、发病到球囊扩张的时间两组间差异无统计学意义.结论hs-CRP是炎性反应的标志物,反映了斑块局部的稳定性;直接PCI患者血浆hs-CRP水平是PCI术后心肌再灌注不良的重要影响因素.
Objective This study was designed to investigate the relationship between high sensitivity C-reactive protein （hs-CRP） level at admission and myocardial perfusion after percutaneous coronary intervention （PCI） in patients with acute myocardial infarction. Methods The study population consisted of 197 patients （154 men, mean age 60. 94 ± 11.62 years） who were admitted to our hospital with first acute myocardial infarction and underwent primary PCI in the infarct-related artery. Myocardial perfusion was evaluated by Thrombolysis In Myocardial Infarction （TIMI） myocardial perfusion grade （TMPG）. Patients were divided into two groups according to TMPG after PCI. Group 1 consisted of 39 patients with TMPG 0-1 and group 2 consisted of 158 patients with TMPG 2-3. Serum hs-CRP levels at admission were measured. Results hs-CRP level at admission was significantly higher in group 1 than that in group 2 （P = 0. 026）. Condusions Higher hs-CRP level at admission in patients with acute myocardial infarction is related to poorer myocardial perfusion post primary PCI.
出处
《中华心血管病杂志》
CAS
CSCD
北大核心
2006年第5期422-424,共3页
Chinese Journal of Cardiology
关键词
心肌梗塞
血管成形术
经腔
经皮冠状动脉
C反应蛋白
心肌再灌注
Myocardial infarction
Angioplasty,transluminal,percutaneous coronary
C-reactive protein
Myocardial reperfusion
