摘要
目的：探讨通心络对未发生卒中的缺血性脑血管病患者治疗作用机制。方法：将入选的266例脑供血不全患者按1：6比例随机分为治疗组（228例）和阳性对照组（38例），并选择36名健康成人作为正常人组。治疗组服用通心络胶囊每日3次，每次2粒，饭后1h服用，并加服阿司匹林80mg，连服15～30dl阳性对照组服用甲磺酸二氢麦角碱，每日3次，每次5mg，饭后1h服用并加服阿司匹林80mg，连服15d。参考美国卒中学会的标准将缺血性脑血管病患者的症状进行分类，并用比色法测定血浆溶血磷脂类标记物血浆溶血磷脂酸C。结果：束发生急性卒中的缺血性脑血管病患者临床症状的分布很不均匀，以表现为行走困难、头晕或失衡，失定向力的1类症状为最常见，达60％以上；表现为突然意识模糊、语言不清或理解困难的2类症状发生最少，不足1％。通心络对改善患者症状有明显作用，在这些患者中，血浆LPA水平明显增高。通心络对LPA的作用具有时间-效应关系，对伴有糖尿病、高血压、高血脂患者，延长治疗时间，效果有增加趋势。结论：在未发生急性卒中缺血性脑血管病患者的症状中，以头晕、行走不稳最为常见，其血浆LPA水平明显增高。通心络对脑供血不全患者有一定的治疗作用。
Objective： To explore the curative effects of Tongxinluo （通心络） on patients with ischemic eerebrovaseular diseases （ICD） and without acute stroke, and study the characters of the changes of lysophospholipid. Methods： Two hundred and sixty-six patients with ICD were randomly divided into treatment group （n=228） and positive control group （n=38） as the ratio of 1 ： 6, and 38 healthy adults were selected as normal controls. Patients in treatment group were treated with Tongxinluo capsules （通心络胶囊） 2 pills for 3 times per day, taking 1 hour after meals, combined with aspirin 80 mg for 15-30 days consecutively. Patients in positive control group took hydergine 5 mg for 3 times per day, taking 1 hour after meals, combined with aspirin 80 mg for 15-30 days consecutively. The clinical symptoms were classified according to the standards of American Stroke Union. Lysophosphatidic acid （LPA） was assayed by colorimetric method. Results： The clinical symptoms of patients with ICD were distributed asymmetrically. The first kind of symptoms, such as trouble in walking, dizziness, loss of balance and incoordination appeared frequently, accounting for more than 60%. Sudden confusion, trouble in speaking or understanding appeared less than 1%. Tongxinluo improved clinical symptoms evidently. The plasma LPA levels were elevated in these patients. The effect of Tongxinluo on reducing LPA levels was time-dose dependent. The effect increased by prolongation of the therapeutic time for patients with diabetes, hypertension and hyperlipemia. Conclusion： Trouble in walk and dizziness occurs more frequently in patients with ICD and without acute stroke, and plasm LPA level is significantly elevated. Tongxinluo is effective in treatment of ICD.
出处
《中国中西医结合急救杂志》
CAS
2006年第3期182-184,共3页
Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care
关键词
脑血管疾病
缺血性
通心络
溶血磷脂酸
ischemic cerebrovascular disease
Tongxinluo
lysophosphatidic acid
