摘要
目的观察自制高分子聚合材料超声造影剂“高聚显”的显影效果、特点及其安全性。方法质量浓度为5%高聚显溶液,按0.25 ml/kg剂量经兔耳缘静脉团注,采用GE Vivid 7彩色多普勒超声诊断仪,12L探头,以不同机械指数(MI),在二次谐波、彩色多普勒及能量多普勒模式下,分别实时动态观察肝血管、肝实质回声强度以及肾多普勒血流信号增强情况,并对肝实质回声强度进行动态定量分析。结果在高、低MI情况下,高聚显均能明显增强肝血管、肝实质回声强度和肾多普勒血流信号,作用时间持续约30 min;造影后肝实质峰值回声强度较造影前平均增加(10.36±2.13)dB。所有兔在实验过程中以及实验后观察2周均未发现明显异常。结论高聚显是一安全、显影效果好、持续时间长、在不同MI状态下均能实现实时超声造影的新型高分子材料超声造影剂。
Objective To explore the effects of the novel high molecular polymer ultrasound contrast agents on enhancing ultrasound imaging and Doppler blood flower signal in vivo experiment. At the same time, experiment was done to explore its safety. Methods Five per cent（mass concentraction） GAOJUXIAN saline water was injected into the ear vein of rabbit（0.25 ml/kg）. Vivid 7 color Doppler ultrasound machine with a 12L probe was used to dynamically observe the ultrasound grey scale imaging and Doppler flow signals of rabbits＇ livers and renals under different mechanic index （MI） and different models, such as harmonic, color Doppler and power Doppler models. And echogenic intensity of the livers was dynamically quantified. Results GAOJUXIAN could enhance the grey scale ultrasound imaging and Doppler flow signals of liver and renal under high or low MI. The enhancement of peak echogenic intensity of the livers after injecting GAOJUXIAN was up to （12.4 ± 2.7）dB. The duration of contrast enhancement was longer than thirty minutes. No death or abnormal behaviors of rabbits were observed within two weeks. Conclusions GAOJUXIAN is a kind of safe contrast agents which can enhance ultrasound imaging greatly at different MI and has a long duration time.
出处
《中华超声影像学杂志》
CSCD
2006年第5期378-380,共3页
Chinese Journal of Ultrasonography
基金
国家自然科学基金重点项目(30430230)
