摘要
目的探讨急性心理应激对不同特质焦虑大学生免疫功能的影响。方法用特质焦虑问卷(TAI)对236名大学生自愿者进行测试,筛选出高、低焦虑组各28名,再将每组随机分为试验组和对照组;用放射免疫法测定血清肿瘤坏死因子α(TNF-α)和白细胞介素6(IL-6)的含量。结果应激后,血清中TNF-α、IL-6均升高[(1.85±0.32)ng/ml],TNF-α[(1.85±0.33)ng/ml]的变化差异有显著性(t=2.28,P<0.05);低焦虑组大学生TNF-α和IL-6浓度的变化与总体上相似(tTNF-α=2.98,P<0.05,tIL-6=0.77,P>0.05);高焦虑组大学生TNF-α的浓度高于对照组,IL-6浓度则有下降的趋势,但差异均无显著性(tTNF-α=0.63,tIL-6=0.47,P>0.05)。结论急性心理应激可导致大学生血清TNF-α、IL-6浓度升高,提示急性心理应激可以引起机体自然免疫功能的增强;心理应激引起低焦虑特质个体自然免疫增强的现象较明显,而对高特质焦虑个体的作用不明显。
Objective To explore the effects of acute psychological stress on immune function in college students with different trait-anxiety. Methods By using Trait Anxiety Inventory （TAI）, high trait-anxiety group and low trait-anxiety group with 28 members each were chosen among the volunteers of 236 college students, and then the two groups were divided into psychological stress group and control group with random means. The concentration of Interleukin-6 （IL-6） and Tumor Necrosis Factor-α （TNF-α）were assayed by using radioimmunity. Resuits In general, the concentration of TNF-α and IL-6 were increased after stress, but only TNF-α were significantly higher（ t = 2.28, P 〈 0.05 ） ; low trait-anxiety college students were similar as the population （ t TNF-α= 2.98, P 〈 0, 05, tIL-6 = 0.77, P 〉 0, 05） ; the concentration of TNF-α of psychological stress were higher than that of control group whereas the concentration of IL-6 lower, there were both no significant differences among high trait-anxiety college students（ tTNF-α = 0.63, tIL-6 = 0.47, P 〉 0.05 ）. Conclusions Acute psychological stress can lead to the increase of the concentration of TNF-α and IL-6 for college students. This support the upregulation of natural immunity. Trait-anxiety personality is one of factors, by which acute psychological stress causes immune function, The influence of acute psychological stress on low trait-anxiety individuals is much higher than that of high trait-anxiety ones or just the opposite, This result may serve as one the potential factors, which explains why some individuals are more likely to suffer from psychosomatic disorder,
出处
《中国行为医学科学》
CSCD
2006年第5期405-406,共2页
Chinese Journal of Behavioral Medical Science
关键词
心理应激
特质焦虑
免疫功能
放射免疫法
Psychological stress
Trait anxiety
Immunity function
Radioimmunity
