Synthesis of Tritium and Deuterium Labelled Agmatine
被引量：1
Synthesis of Tritium and Deuterium Labelled Agmatine
摘要
An efficient procedure for the synthesis of agmatine labelled with tritium and deuterium is reported. The final tritiated product 4 was obtained with a specific activity of 40 Ci/mmol and a radiochemical purity of 95%.
参考文献8
-
1[1]R.B.Su,J.Li,B.Y.Qin,ActaPharmacol.Sin.,2003,24,631.
-
2[2]J.Li,X.Li,G.Pei,B.Y.Qin,Acta Pharmacol.Sin.,1999,20,232.
-
3[3]A.Kuzirian,E.Meyhofer,L.Hill,J.T.Neary,D.L.Alkon,J Neurocytol.,1986,15,629.
-
4[4]D.Stickle,A.Bohrer,R.Berger,J.Morrissey,et al.,Anal.Biochem.,1996,238,129.
-
5[5]D.M.Colleluori,D.E.Ash,Biochemistry,2001,40,9356.
-
6[6]F.Effenberger,S.Heid,Synthesis,1995,9,1126.
-
7[7]J.B.Ducep,B.Heintzelmann,K.Jund,et al.,Tetrahedron:Asymmetry,1997,8,327.
-
8[8]Y.B.Lee,M.H.Park,J.E.Folk,J.Med.Chem.,1995,38,3053.
同被引文献8
-
1Satriano J,Matsufuji S,Murakami Y,et al.Agmatine suppresses proliferation by frameshift induction of antizyme and attenuation of cellular polyamine levels[J].Journal of Biological Chemistry,1998,273(25):15313-15316.
-
2Golding B,Mitchinson A,et al.Transactions:Organic and Bio-Organic Chemistry[J].Journal of the Chemical Society,1999,(3):349-356.
-
3李松,郑志兵,何红夏,等.氘和氚标记的胍丁胺及其在生化与医药研究上的应用:CN,1834085A[P].2005-03-14.
-
4Vargiu C,Cabella G,Belliardo S,et al.Agmatine modulates polyamine content in hepatocytes by inducing spermidine/spermine acetyltransferase[J].European Journal of Biochemistry,1999,259(3):933-938.
-
5Dudkowska M,Lai J,Gardini G,et al.Agmatine modulates the in vivo biosynthesis and interconversion of polyamines and cell proliferation[J].Biochimica et Biophysica Acta,2003,1619(2):159-166.
-
6Kribben B,Heller J,Trebicka J,et al.Agmatine(decarbo xylated arginine),a modulator of liver cell homeostasis and proliferation[J].Naunyn-Schmiedebergs Arch Pharmacol,2004,369(2):160-165.
-
7Molderings G,Kribben B,Heinen A,et al.Intestinal tumor and agmatine(decarboxylated arginine)-Low content in colon carcinoma tissue specimens and inhibitory effect on tumor cell proliferation in vitro[J].Cancer,2004,101(4):858-868.
-
8Wolf C,Bruss M,Hanisch B,et al.Molecular basis for the antiprolliferative effect of agmatine in tumor cells of colonic,hepatic,and neuronal orion[J].Molecular Pharmacology,2007,71(1):276-283.
二级引证文献3
-
1何晓强,李安梅,朱士荣.硫酸羟胍的绿色合成工艺研究[J].化学与生物工程,2015,32(3):60-61.
-
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-
3颜瑞,周迎梅,王田田,麻玉贞,原如昭,纪永刚.胍基化合物的分类及制备方法[J].生物化工,2019,5(2):154-156. 被引量：2
-
1Zhi Xian WANG,Wu Cheng ZHU and Ru Yun JI(Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 200031).OPIOID δ RECEOTIR IRREVERSIBLE INHIBITORS 3.SYNTHESIS OF AMIDE ANALOGHES OF SUPERFIT CARFIT AND METHOFIT[J].Chinese Chemical Letters,1995,6(9):765-768.
-
2张树芹,侯万国.Sorption Removal of Pb（Ⅱ） from Solution by Uncalcined and Calcined MgAl-Layered Double Hydroxides[J].Chinese Journal of Chemistry,2007,25(10):1455-1460. 被引量：2
-
3马桂林,许宜铭.二（草酸根）,N,N,N`—三甲基乙二胺合钴（Ⅲ）配合物的重氢...[J].扬州师院学报（自然科学版）,1991,11(2):40-44.
-
4杨勇,窦丹丹.三重和四重氢键体系:设计、结构和应用[J].化学进展,2014,26(5):706-726. 被引量：7
-
5Wang, HY,Au, CT.Investigation of Deuterium Isotope Effects in the Carbon Dioxide Reforming of Methaneto Syngas over Rhodium Catalysts[J].Chinese Chemical Letters,1996,7(11):1047-1050.
-
6白炳莲,李敏.基于多重氢键的超分子液晶研究[J].高分子通报,2005(1):44-49. 被引量：4
-
7周勇,王萍亚,赵华,蒋玲波,戴意飞,张薇英.离子色谱法测定冷冻海产品中的生物胺[J].食品工业,2014,35(5):238-241. 被引量：22
-
8S.M. Motevalli,M.R. Pahlavani,M. Azimi.Effects of Isotopic Concentrations on Thermodynamic Parameters of Deuterium-Tritium Mixtures[J].Communications in Theoretical Physics,2013,60(7):108-112.
-
9ZHANG Zhu-jun , ZHANG Su-sen and ZHANG Xin-rong (Department of Chemistry, Shaanxi Normal University, Xian, 710062).A New Chemiluminescence Amplification Reaction for the Determination of HRP and Labelled HRP[J].Chemical Research in Chinese Universities,1993,9(4):314-316.
-
10Bai Ling XU,Zong Ru GUO,Xiao Tian LIANG,Guang Zhong YANG (Institute of Materia Medica, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100050).Study on the Mechanism of the Rearrangement Reaction of 3-n-Butylphthalide by Deuterium-Labelling[J].Chinese Chemical Letters,1997,8(6):479-482.
