摘要
目的:了解静脉吸毒人群前瞻性队列研究2年随访的HIV血清抗体阳转率和保持率情况。方法:于2002年11月,在四川省西昌市从社区招募了HIV血清抗体阴性的静脉吸毒人群前瞻性研究队列333人,队列每6个月随访1次和采集血样进行HIV抗体检测,以及分析队列本底的静脉吸毒人群社会人口学和HIV高危行为特征与队列保持率的关系。结果:静脉吸毒人群队列研究2年随访的HIV血清抗体阳转率为2.53/100人年(95%CI,1.10-3.97)和保持率为75.7%(252/333)。在多因素logistic回归模型分析中,与队列保持率的关系有统计学意义的变量为:彝族(OR,0.52;95%CI,0.29-0.91)、6个月回访(OR,4.72;95%CI,2.69-8.28)、和近3个月静脉吸毒频率高(OR,2.06;95%CI,1.12-3.80)。结论:本研究队列静脉吸毒人群HIV血清抗体阳转率较高和彝族静脉吸毒人群队列保持率低。
Objective： To investigate the HIV seroconversion and cohort retention in a 2-year follow-up study among injection drug users （IDUs）. Methods： In November 2002, a community-based baseline survey was conducted to recruit 333 HIV-seronegative IDUs for a prospective cohort study in Xichang City of Sichuan Province. Follow-up visits were conducted every 6 months to analyze risk factors associated with cohort retention for subjects＇ baseline demographic and behavioral characteristics, and blood specimens were also collected to test for antibodies against HIV. Results： During the 24-month follow-up period, HIV incidence and cohort retention rate were 2.53 per 100 person-year （95% confidence interval [CI]：1. 10, 3.97） and 75.7%, respectively. Multivariate logistic regression model showed that risk factors were significantly associated with cohort retention included Yi nationality （OR, 0.52; 95%CI, 0.29-0.91）, appearing at the 6-month follow-up visit （OR, 4.72; 95%CI, 2.69-8.28）, and drug injection in the past 3 months≥6 times/day （OR, 2.06; 95%CI, 1.12-3.80）. Conclusion： The study showed HIV seroconversion was high and cohort retention of Yi nationality was low in this cohort, respectively.
出处
《中国药物滥用防治杂志》
CAS
2006年第2期63-66,共4页
Chinese Journal of Drug Abuse Prevention and Treatment
基金
国家十五科技攻关课题项目(2004BA719A01
2004BA719A02)
国家自然科学基金项目(30571612
10501052)
卫生部艾滋病防治应用性研究项目(WA2003-13)
