摘要
目的探讨输液器对酚妥拉明的吸附作用及其影响因素。方法采用紫外分光法测定不同浓度,不同输注速度的酚妥拉明在通过输液器前及输液器后各时段药物浓度。结果不同输注速度及不同浓度酚妥拉明注射液通过输液器即刻其浓度显著下降(P<0.05,P<0.01)。同时段不同输注速度相同浓度间差异无显著性意义(均P>0.05);相同输注速度不同浓度间差异有显著性意义(均P<0.05),其中浓度为16 mg/100 ml的吸附量显著高于浓度为8 mg/100ml和4 mg/100 ml(均P<0.01),后两者之间差异无显著性意义(P>0.05)。结论输液器对酚妥拉明有显著吸附作用,浓度越高吸附作用越大,其吸附作用随输注时间延长而降低,30 min后基本恢复至原液水平。
Objective To explore the absorption of phentolamine in transfusion system. Methods By using the ultraviolet spectrometer, the concentrations of phentolamine at different time points before and after passing through the transfusion system, in different infusion concentrations and velocity, were measured. Results The concentration of phentolamine was obviously decreased immediately after passing through the transfusion system at the different infusion velocity and different concentrations （P〈0.05, P〈0. 01 ）. At the same time point but different infusion velocity and same concentrations, no difference was found （all P〉0.05）. At the same infusion velocity and different concentrations, the difference was significant （all P〈0. 05）. The absorption amount of 16 mg/100 ml was significantly higher than that of 8 mg/100 ml and 4 mg/100 ml （all P〈0. 01）. Concentration of 8 mg/100 ml and 4 mg/100 ml were not significant difference （all P〉0. 05）. Conclusion Transfusion system could obviously absorb phentolamine. The higher the phentolamine, the greater the absorption. The absorption was decreased with the prolongation of transfusion time. Thirty min later, the absorotion was returned to the original level.
基金
湖北省卫生厅科研基金项目(No.JX2C28)
关键词
酚妥拉明
输液器
吸附
实验研究
phentolamine
transfusion system
absorption
experimental study
