摘要
目的:了解我国应用氯氮平引起脑电图(EEG)异常及癫疒间发作的情况。方法:通过数据库及手工检索收集1979年至2004年国内有关氯氮平所致EEG异常及癫疒间发作的文献143篇,其中癫疒间发作的个案报道30例。结果:异常发生率为67.20%(5 543/8 249),癫疒间发作的发生率为0.95%(297/31 185)。资料显示,氯氮平的口服剂量越大,发生EEG异常及癫疒间的风险就越大、EEG异常程度就越重。结论:服用氯氮平治疗的患者定期进行EEG及血药浓度监测十分必要。
Objective：To review the literatures on clozapine-induced electroencephalographic abnormalities and seizure in China. Method： 143 reports （1979-2004） were collected by China National Knowledge Infrastructure （CNKI） and China Biology Medical Disc （CBMDISC） and handwork. 30 of them were case reports about seizure. Results：The incidence of EEG abnormalities and seizure was 67.20% （5 543/8 249） and 0.95% （297/31 185） respectively. It was showed that the higher daily dose of clozapine was the greater risk of abnormal EEC and seizure may be, and the more severity of abnormal EEG may be. Conclusion：It is very important for monitoring EEG and serum clozapine concemtration in patients with clozapine regularly.
出处
《临床精神医学杂志》
2006年第2期78-79,共2页
Journal of Clinical Psychiatry
关键词
氯氮平
脑电图
癫癇发作
clozapine
electroencephalography
seizure
