摘要
造血干细胞(hematopoieticstemcell,HSC)的自我更新维持每天血细胞数量,Bmi-1基因属Polycomb(PcG)基因家族成员。最近研究表明,Bmi-1在调控正常和白血病干细胞的自我更新中起重要作用,本文就Bmi-1的结构,功能和在造血干细胞的自我更新中的作用作一简要综述。
Self-renewal of hematopoietic stem cells is vital for the sustained daily production of blood cells. The Bmi-1 gene is a putative oncogene belonging to the Polycomb group family. Recent studies have shown that the Polycomb-group gene Bmi-1 is indispensable for regulation of self-renewal of normal and leukemic stem cells. The research progress on structure and function of Bmi-1 gene, and its role in self-renewal of hematopoietic stem cells was reviewed.
出处
《中国实验血液学杂志》
CAS
CSCD
2006年第2期413-415,共3页
Journal of Experimental Hematology
