摘要
目的:应用Meta分析方法探讨中国女性被动吸烟与乳腺癌之间的关联。方法:实验于2005-10/11在青岛大学医学院预防医学教研室完成。通过计算机检索中国期刊网全文数据库及维普中文科技期刊全文数据库,收集国内1989-01/2005-08公开发表的有关乳腺癌危险因素的研究文献。文献纳入标准:①研究地点在中国。②研究因素中包括被动吸烟。③效应指标为OR。利用Meta分析的方法对检索出的符合要求的文献进行再分析,定量综合评价被动吸烟与乳腺癌的关系。OR>1,说明暴露因素是疾病的危险因素;OR<1,提示暴露因素是疾病的保护因素;OR=1,揭示暴露与疾病间无关联。95%CI为总体OR的可信区间,该区间不跨1,OR有统计学意义,否则无统计学意义。结果:检索出符合纳入标准的10篇病例-对照研究,共累计病例1879例,对照2040例。10项研究无一致性,Q=20.13,P<0.05;被动吸烟的OR合并(随机效应模型)为1.94,OR合并的95%CI为(1.80～2.10)。结论:被动吸烟与乳腺癌发病有关联,被动吸烟女性患乳腺癌的风险是无被动吸烟女性的1.94倍。
AIM： To explore the relationship between passive smoking and female breast cancer in China with Meta-analysis.
METHODS： The experiment was conducted in Department of Preventive Medicine, Medical College of Qingdao University from October to November 2005. A computer based search of Chinese journal full-text database and VIP Chinese science and technology journals full-text database was performed. Domestic researches about risk factors of female breast cancer published between Junuary 1989 to August 2005 were collected. Inclusive criteria： ① Studies located in China. ②Researching factors included passive smoking. ③Effective indicators were odds ratio （OR）. Papers which were in accordance with the requirement were reanalyzed with Meta-analysis. Relation between passive smoking and female breast cancer were comprehensively and quantitatively evaluated. OR〉1 indicated that factor of exposure was the risk factor of disease; OR 〈1 suggested that factor of exposure was the protective factor of disease; OR=1 revealed that there were no correlation between factor of exposure and diseases. 95 % CI was the confidence interval of total OR. There were statistical significances if CI was below 1, otherwise, there were no statistical significances.
RESULTS： Ten case-control studies in accordance with the inclusive criteria were selected including 1 879 patients and 2040 controls. Significant heterogeneity was detected among 10 studies （Q=20.13, P 〈 0.05）. Combined estimate of OR of ever exposured to passive smoking （random effect models） was 1.94 and its 95% CI was 1.80-2.10 .
CONCLUSION： There are association between passive smoking and female breast cancer. Risk of breast cancer in women suffering from passive smoking is 1.94 times of that in women without passive smoking.
出处
《中国临床康复》
CSCD
北大核心
2006年第16期6-8,共3页
Chinese Journal of Clinical Rehabilitation
