摘要
[目的]观察丹参水溶性成分丹酚酸B和脂溶性成分丹参酮ⅡA对家兔动脉粥样硬化模型血清一氧化氮(NO)及甘油三酯(TG)浓度的影响,以寻找其作用耙点。[方法]复制家兔动脉粥样硬化模型,分别用放射性免疫方法和比色法检测血清NO和TG浓度,观察丹酚酸B和丹参酮ⅡA抗动脉粥样硬化的作用异同。[结果]丹酚酸B和丹参酮ⅡA都能增加动脉粥样硬化家兔血清NO浓度,降低血清TG浓度。但升高NO的作用丹参酮ⅡA优于丹酚酸B;降低TG作用丹酚酸B优于丹参酮ⅡA。[结论]丹参水溶性成分与脂溶性成分都能调节血清NO及TG浓度而达到抗动脉粥样硬化的作用,但具体作用机制有所不同。
[Objective] To study the influence of water-soluble active principle （salvianolic acid B） and fat-soluble active principle （tanshinone Ⅱ A） on the level of nitric oxide （NO） and triglyc- eride （TG） in sera of atherosclerosis rabbits. [Methods] Atherosclerosis was initiated in rabbits by feeding cholesterol and oil.The influence of salvianolic acid B and tanshinone ⅡA on sera NO and TG were observed by radio immunity and GPO-PAP. [Results] Both of the salvianolic acid B and the tanshinone Ⅱ A could markedly decrease the level of TG and significantly increase the NO; but the tanshinone Ⅱ A was significantly better than the salvianolic acid B on NO, the salvianolic acid B was better significantly better than the tanshinone Ⅱ A on TG. [Conclusion] The salvianolic acid B and tanshinone Ⅱ A both could inhit atherogenesis of hyperlipid-fed rabbits by modulate the NO and TG, but the mechanism is not entire the same.
出处
《天津中医学院学报》
2006年第1期32-34,共3页
Journal of Tianjin College of Traditional Chinese Medicine
基金
天津市自然科学基金项目(023611611)。
