摘要
目的 监测从我院患者中分离到的阴沟肠杆菌耐药性。方法 用纸片琼脂扩散法测定阴沟肠杆菌对10种抗菌药物的耐药性，检测产超广谱俨内酰胺酶，并应用三维试验检测AmpC酶。结果 从医院住院患者分离到的74株阴沟肠杆菌对9种抗菌药物的耐药率较高（40．5％～91．8％），且分离到ESBLs及AmpC酶分别为31株（41．89％）和10株（13．5％），两种酶同时存在者为6株（6．1％），总产酶株47株，占63．5％。而亚胺培南却对74株阴沟肠杆菌均敏感。结论 亚胺培南可作为治疗产ESBLs酶和AmpC酶阴沟肠杆菌所引起的严重感染的首选药物。
OBJECTIVE To monitor the Enterobacter cloacae resistance in our hospital patients. METHODS Disk susceptibility tests were performed for detection of E. cloacae resistance to 10 antibiotics, Detection of extendedspectrum β-lactamases and AmpC β-lactamase was conducted by three-dimensional extract test. RESULTS Seventy four strains of E. cloacae were isolated from our hospital patients, its had high resistant rate to 9 antibiotics（from 40. 5% to 91.8%）, Among 74 strains of E. cloacae, 10 isolates（13.5%） were considered as AmpC enzyme producing, 31 strains（41.89%） were ESBLs-producing, 6 strains（8.1%） were producing both of them. Total detection of AmpC β-lactamase, or the production of ESBLs, or both of them were 47 strains （63.5%）. Only imipenem was effective for all E. cloacae. CONCLUSIONS For the serious infection induced by E. cloacae producing AmpC β-lactamase or ESBLs, imipenem is first choice of treatment.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2006年第3期343-344,共2页
Chinese Journal of Nosocomiology
