摘要
目的:探讨阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者睡眠中觉醒与日间嗜睡的关系及持续气道正压通气(CPAP)对觉醒和日间嗜睡的治疗效应。方法:62例OSAHS患者和12例单纯鼾症患者均记录Epworth评分(EP)、睡眠潜伏期(SL)、呼吸紊乱指数(AHI)、最低血氧饱和度(minSaO2)、氧减饱和度指数(ODI4)、氧饱和度低于90%时间百分比(SLT90%)及呼吸紊乱相关觉醒指数(B-ArI),并将EP、SL分别与B-ArI、minSaO2、ODI4、SLT90%作多元线性回归和相关分析,并比较12例OSAHS患者CPAP治疗前后各项指标变化。结果:EP和SL均与B-ArI关系最密切(EP:R=0.708,R2=0.502,F=72.539,P<0.001;SL:R=0.534,R2=0.285,F=28.673,P<0.001)。CPAP治疗后B-ArI、EP显著降低,SL显著增加(P<0.001)。结论:OSAHS患者睡眠中觉醒与日间嗜睡相关,B-ArI可以预计主客观日间嗜睡程度。CPAP对觉醒和日间嗜睡有很好的治疗效应。
Objective： To explore the relationship between arousal and daytime sleepiness in patients with obstructive sleep apnea hypopnea syndrome and the cure effect of arousal and daytime sleepiness using CPAP. Methods： Sixty-two OSAHS patients and twelve simple snorers were recorded to EP, sleep latency （SL）, apnea hypopnea index （AHI）, minimum SaO2 （nfinSaO2）, number of oxygen desaturation 〉4% per hour （ODI4）, percentage of time when oxygen saturation lower than 90% （SLT90%） and breathing disorder related arousal index （B-ArI） were recorded, then correlation and multiple regression analysis were performed on EP, SL to B-ArI, minSaO2,ODI4,SLT90%, respectively. Finally, variation of every index that was before and after the treatment in 12 patients with OSAHS was compared. Results： EP （R = 0.708,R^2 = 0.502,F = 72.539,P 〈 0.001） and SL （R = 0.534,R^2=0.285, F = 28.673, P 〈 0.001 ）were all the closest related to B-ArI.B-ArI and EP decreased,SL increased significantly after CPAP treatment （P 〈 0.001 ）. Conclusion： Arousal is related to daytime sleepiness in patients with obstructive sleep apnea hypopnea syndrome. B-ArI can predict the degree of subject and object daytime sleepiness. CPAP is effective to decrease arousal and daytime sleepiness.
出处
《天津医药》
CAS
北大核心
2006年第1期26-28,共3页
Tianjin Medical Journal
关键词
睡眠呼吸暂停
阻塞性
觉醒
睡眠障碍
正压呼吸
sleep apnea, obstructive arousal sleep disorders positive-pressure respiration
