摘要
西妥昔单抗是一种嵌合的单克隆抗体,它选择性地与表皮生长因子受体〔存在于正常细胞(皮肤和毛发细胞)和许多肿瘤细胞(如结肠癌、直肠癌)的表面〕特异性地结合,从而抑制肿瘤细胞的增殖,诱导肿瘤细胞凋亡。本文综述了西妥昔单抗的药理作用及临床评价。
Cetuximab is a chimeric monoclonal antibody highly selective to bind the epidermal growth factor receptor （ EGFR）, which is found on the surface of normal cells （ such skin and hair cells） and some types of cancer cells including colorectal cancer. Thus, the proliferation of the tumor cells are inhibited and apoptosis of tumor cells by inducing, The pharmacologic actions of cetuximab and its clinical evaluation are reviewed in this paper.
出处
《中国全科医学》
CAS
CSCD
2006年第4期317-318,共2页
Chinese General Practice
关键词
西妥昔单抗
受体
表皮生长因子
药理作用
临床评价
Cetuximab
Receptor, epidermal growth factor （EGFR）
Pharmacological actions
Clinic evaluation
