摘要
目的了解学龄前儿童维生素B12（VB12）的营养水平，探讨血清VB12水平与营养性贫血的关系，并对相关因素进行分析。方法随机对重庆市四所幼儿园351名2—7岁儿童进行体格测量及血常规筛查，对其中177名进行膳食调查、血清VB12测定。结果学龄前儿童血清VB12平均水平为552pg／ml，VB12缺乏（血清VB12〈200pg／ml）检出率为4．5％（8／177），边缘性缺乏（血清VBl2200—300pg／m1）检出率为10．7％（19／177）。学龄前儿童血清VB12无性别和年龄差异（P〉0．05）。血清VB12水平与血红蛋白水平无相关性。多因素逐步回归分析显示血清VB12水平主要受膳食VB12摄入量的影响（P=0．03）。8例VB12缺乏儿童体格发育正常，仅1例为小细胞性贫血，其余7例红细胞数目、红细胞平均体积及平均红细胞血红蛋白量均在正常范围内。结论学龄前儿童血清VB12水平明显高于成人，提示血清VB12水平存在年龄差异，2—7岁儿童血清VB12较稳定。血清VB12水平与血红蛋白水平无相关性，儿童VB12缺乏不一定是典型的大细胞性贫血。膳食中VB12含量是影响儿童血清VB12水平的重要因素。
Objective To explore the levels of serum vitamin B12 （VBI2） in preschool children, determine the relationship between the levels of serum VB12 and anemia, and analyze the effects of several factors related to the level of serum VB12. Methods From March 2005 to July 2005, the weight, height and complete blood count （ CBC ） were studied in 351 children aged 2 to 7 years from 4 kindergartens of Chongqing. The concentrations of serum VB12 and the dietary survey of 177 of the children were evaluated. Results The average level of serum VB12 for the preschool children was 552 pg/ml. The levels of serum VB12 in 4.5% （ 8/177 ） of the children were below 200 pg/ml （ defined as VB12 deficiency ） , in 10.7% （ 19/177 ） of the children were 200 - 300 pg/ml （ called marginal deficiency ） . There were no significant differences in the levels of serum VB12 between boys and girls. And there was no correlation between the levels of serum VB12 and hemoglobin. The results of muhivriate stepwise regression analysis showed that the concentrations of serum VB12 were mainly influented by the contents of VB12 in the foods （P =0.03）. Eight of the children with normal growth and development were diagnosed as VB12 deficiency, only one of them was diagnosed microcytic hypochromatic anemia. The ranges of Hb, MCV and MHC were normal in the other 7 children. Conclusions The levels of serum VB12 of preschool children were higher than that of adults, suggesting that the levels of serum Vll2 change with age. There were no significant differences in the levels of serum VB12 in 2 -7 years old children between sex and ages. The levels of serum VBt2 were not correlated with the concentrations of hemoglobin. Macrocytic anemia may not occur in preschool children with VB12 deficiency. The intake of Vll2 from the diets was one of the important factors for preschool children to keep the normal ranges of serum VB12. It is beneficial for children to consume foods enriched with VB12 to keep the normal level of serum VB12.
出处
《中华儿科杂志》
CAS
CSCD
北大核心
2006年第1期7-10,共4页
Chinese Journal of Pediatrics
