摘要
目的 探讨低浓度5-氟尿嘧啶（5-FU）抑制血管增生在瘢痕疙瘩临床综合治疗中的作用。方法 35名瘢痕疙瘩患者，共51个瘢痕疙瘩。平均病史9．7年。以5-Fu2～5mg／ml瘢痕内注射，1次／2周。3～6次后辅以糖皮质激素注射。平均治疗时间为10．29个月。结果 低浓度5-FU抑制瘢痕疙瘩血管增生有效率为96．77％；在治疗6个月以上的患者中，5-FU结合糖皮质激素治疗瘢痕疙瘩的总有效率为97．14％，其中完全缓解者占45．71％，极大缓解者占48．57％，部分缓解者占2．86％．未缓解者占2．86％。结论 利用低浓度5-FU抑制血管增生的作用结合糖皮质激素治疗瘢痕疙瘩具有良好的疗效。
Objective To explore the effect of intralesional injection of low concentration 5-fluorouracil （5-FU） on inhibition of angiogenesis of keloid. Methods 35 patients with 51 keloids were treated with intralesional injection of 5-FU （2 - 5 mg/ml） biweekly. After 3 - 6 times of injection, the keloids were treated with intralesional injection of corticosteroid. The average period of treatment was 10.29 months. Results The efficacy of inhibiting keloid angiogenesis by low concentration of 5-fluorouracil was 96.77 % . For the patients who were treated over 6 months with both 5-FU and corticosteroid, the total efficacy was 97.14% . Among them, 45.71% of keloids achieved complete remission, 48.57% mostly remission, 2.86% partial remission and 2.86% no remission. Conclusion Inhibition of keloid angiogenesis with intralesional injection of low concentration of 5-fluorouracil along with corticosteroid injection can achieve satisfactory result.
出处
《中华整形外科杂志》
CAS
CSCD
北大核心
2006年第1期44-46,共3页
Chinese Journal of Plastic Surgery
