摘要
目的探讨胃肠道外间质瘤（EGISTs）的临床特征、诊断及治疗。方法回顾性分析1999年9月～2004年12月我院收治的EGISTs的临床病理资料。结果发生于小肠系膜2例、腹膜后5例，表现为腹部肿块7例（100％）、腹部不适3例（42．9％）、体重减轻3例（42．9％）。免疫组化检查：CD117、CD34、Vimentin阳性率分别为100％（7／7）、57．1％（4／7）、100％（7／7）。手术切除6例，活检术1例。1、3、4年生存率分别为85．7％（6／7）、42．9≥％（3／7）、14．3％（1／7），1例复发后服格列卫获得部分缓解。结论EGISTs少见，预后差，完整的外科手术切除是最有效的治疗方法，格列卫是有效的靶向治疗药物。
Objective To study the clinical manifestations, diagnosis and treatments of extragastrointestinal stromal tumors （EGISTs）. Methods The clinical and pathological data of 7 patients with EGISTs treated in our hospital from September 1909 to December 2004 were analyzed retrospectively. Results Of the 7 patients, 2 cases arose from the mesentery, and 5 cases from retoperitoneurn. The most common clinical presentations of EGISTs were abdomen mass （100~）, abdominal pain or discomfort （42. 9%）, lose weight （42. 9%）, and so on. Immunohistochemical staining showed： positive rates of Vimentin, CD117 and CD34 were 100%（7/7）, 57. 1% （4/7）, 100% （7/7）, respectively. Of the 7 patients, 6 underwent surgical resection, and 1 underwent incision biopsy. The overall 1-, 3-, 4-year survival rates were 85. 7~, 42. 9%, 14. 3~, respectively. One patient received Gleevec therapy after recurrence, and the result was partial remission. Conclusion EGISTs is a rare disease with poor prognosis. Extension resection is one of the most effective measures to EGISTs. And Gleevec is a highly effective target drug to EGISTs.
出处
《腹部外科》
2006年第1期37-38,共2页
Journal of Abdominal Surgery
