摘要
聚酮化合物的组合生物合成是当前国际化学与生物学交叉学科研究的热点之一,也正在发展成为药物创新超常规的重要手段。本文对近十年来聚酮化合物,特别是I型聚酮化合物的组合生物合成的常用技术和方法学发展进行了回顾和展望。
Polyketide compounds and their biosynthesis by combinatorial approaches had received great attention as a cross-disciplinary subject in a new filed of chemical biology for its importance and great potential to create brand new drug in future. In this review, we hope to summarize methods and technologies which had been developed over past ten years or so for the imaginative discovery of novel polyketide compounds by combinatorial biosynthesis, which incorporate genetic, chemical and biochemical, bioinformatic and biotechnological approaches.
出处
《中国抗生素杂志》
CAS
CSCD
北大核心
2006年第1期6-14,18,共10页
Chinese Journal of Antibiotics
关键词
聚酮化合物
聚酮合酶
组合生物合成
Polyketide
Poly.ketide synthase
Combinatorial biosynthesis
