摘要
Two novel complexes [Cu（TATP）（L-Leu）（H2O）]NO3·H2O and [Cu（TATP）L-Met)（H2O）]NO3·0.5H2O（TATP=1,4,8,9-tetraazatriphenylene,L-Leu=L-Leucinate,L-Met=L-Methioninate）were synthesized and characterized by elemental analysis,molar conductivity,infrared absorption spectrum,electronic absorption spectrum and DTA-TGA.The results showed that both of the complexes had a distorted square-pyramidal geometry with two nitrogen atoms of TATP and one amino nitrogen and one carboxylate oxygen atoms of L-Leu/L-Met at the equatorial positions,and one water oxygen at the axial position.The SOD-Like activity of the complexes was determined by NBT-illumination method.The result indicated that the complexes possessed excellent SOD-like activity and showed 50% inhibition ration in the concentration of 0.355 μmol·L-1 and 0.185 μmol·L-1,respectively.The greater SOD-like activity of the complex[Cu（TATP）（L-Leu）（H2O）]NO3·H2O may be attributed to the smaller spatial hindrance of the side-chain group of L-Met.
Two novel complexes [ Cu （ TATP ） （ L - Leu ） （ H2O ） ] NO3 · H2O and [ Cu （TATP） L - Met） （ H2O ） ] NO3 · 0.5 H2O （ TATP = 1,4,8,9 - tetraazatriphenylene, L - Leu = L - Leucinate ,L - Met = L - Methioninate ） were synthesized and characterized by elemental analysis, molar conductivity,infrared absorption spectrum, electronic absorption spectrum and DTA- TGA. The results showed that both of the complexes had a distorted square - pyramidal geometry with two nitrogen atoms of TATP and one amino nitrogen and one carboxylate oxygen atoms of L - Leu/L - Met at the equatorial positions, and one water oxygen at the axial position. The SOD - Like activity of the complexes was determined by NBT - illumination method. The result indicated that the complexes possessed excellent SOD - like activity and showed 50% inhibition ration in the concentration of 0. 355 μmol · L^-1 and 0. 185 μmol · L^-1, respectively. The greater SOD - like activity of the complex [ Cu （ TATP ） （L - Leu） （ H2O） ] NO3 · H2O may be attributed to the smaller spatial hindrance of the side - chain group of L - Met.
出处
《化学研究与应用》
CAS
CSCD
北大核心
2006年第1期76-79,共4页
Chemical Research and Application
基金
广东省自然科学基金(04105986)重点项目资助
华南农业大学校长基金(2003X004)项目资助
