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P504S、34βE12在前列腺癌诊断中的应用 被引量：1

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摘要 目的探讨高分子角蛋白34βE12和α-甲酰基-辅酶A P504S表达在良性前列腺增生和前列腺癌病理诊断中的应用价值。方法对50例前列腺癌、32例良性前列腺增生（BPH）标本进行P504S、34βE12免疫组化染色。结果P504S、34βE12阳性表达在前列腺癌与良性前列腺增生两组间差异有显著性（P〈0．01）。前列腺癌Gleason评分2～6分与7～10分P504S阳性表达两组间构成比差异有显著性（P〈0．05）。结论P504S、34βE12免疫组化表达对前列腺癌的病理诊断具有重要意义。
作者 廖旭慧 赵碧芬 王维新 欧阳露
机构地区 浙江省丽水市人民医院病理科
出处 《临床医学》 CAS 2006年第1期65-66,共2页 Clinical Medicine
关键词 P504S 34ΒE12 前列腺癌 诊断
分类号 R737.25 [医药卫生—肿瘤]
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参考文献10

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同被引文献5

  • 1Xu J,Stolk JA,Zhang X,et al.Identification of differentially expressed genes in human prostate cancer using subtraction and microarray[J].Cancer Res,2000; 60(6):1677-1682.
  • 2Jiang Z,Woda BA,Rock KL,et al.p504s:a new molecular marker for the detection of prostate carcinoma[J].Am J surg Pathol,2001 ;25 (11):1397-1404.
  • 3Luo J,Zha S,Gage WR,et al.Alpha-methylacyl-CoA racemase:a new molecular marker for prostate cancer[J].Cancer Res,2002; 62 (8):2220-2226.
  • 4Rubin MA,Zhou M,Dhanasekaran SM,et al.Alpha-methylacyl coenzyme A racemase as a marker for prostate cancer[J].JAMA,2002; 287 (13):1662-1670.
  • 5Zhou M,chinnaiyan AM,Kleer CG,et al.Alpha-methylacyl-CoA racemase:a novel tumor marker over-expressed in sereial human cancers and their precursor leisions[J].Am J Surg Pathol,2002;26(7):926-931.

引证文献1

临床医学
2006年 第1期

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