摘要
目的探讨瘦素(leptin,Lep)和瘦素受体(leptin receptor,LR)在子痫前期患者胎盘组织中的表达变化及意义。方法应用免疫组织化学染色及图像分析方法检测子痫前期38例(子痫前期组;其中轻度子痫前期16例,重度子痫前期22例)和正常妊娠妇女20例(对照组)胎盘组织中Lep和LR的表达及定量。结果①子痫前期组胎盘组织Lep表达灰度(46.506±3.332)较对照组(27.516±3.083)高,差异有统计学意义(t=21.153,P<0.01);轻、重度子痫前期组之间相比较,差异无统计学意义(P=0.246)。②LR在对照组、轻度和重度子痫前期组之间比较,差异均无统计学意义(F=1.100,P>0.05)。结论Lep通过其受体以自分泌和(或)旁分泌的作用参与了子痫前期的发病。
Objective To investigate the expression of leptin （Lep） and leptin receptor （LR） in preeclamptic placenta. Methods Expression of Lep and LR of placenta were determined by immunohistochemisty staining and image analysis and compared between 20 cases of normal pregnancy and 38 cases of mild and severe preeclampsia groups. Results （1）Intensity of Lep immnostaining in trophoblast was significantly higher in preeclampsia group （46. 506 ± 3. 332 ） compared with that of normal controls （ 27, 516 ± 3. 083 ） （ P 〈 0.01 ）, but there was no significant difference between the severe and mild preeclampsia groups （ P = 0. 246 ）. （2） There was no significant difference in immunostaining for leptin receptor betweert both severe and mild preeclampsia compared with controls （ F = 1. 100, P 〉0.05）. Conclusion Lep dependent on its receptor may influence pathogenesis of preeclampsia by autocrine and（or） paracrine.
出处
《中原医刊》
2006年第1期1-3,共3页
Central Plains Medical Journal
基金
河南省自然科学基金项目(0211042900)
关键词
瘦素
瘦素受体
子痫前期
Leptin
Leptin receptor
Preeclampsia
